Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia

Heng Choon Cheong, Polly Soo Xi Yap, Chun Wie Chong, Yi Ying Cheok, Chalystha Yie Qin Lee, Grace Min Yi Tan, Sofiah Sulaiman, Jamiyah Hassan, Negar Shafiei Sabet, Chung Yeng Looi, Rishein Gupta, Bernard Arulanandam, Sazaly AbuBakar, Cindy Shuan Ju Teh, Li Yen Chang, Won Fen Wong

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12 Citations (Scopus)


The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. In this study, we profiled the cervical microbial composition of a population of 70 reproductive-age Malaysian women; among which 40 (57.1%) were diagnosed with genital C. trachomatis infection, and 30 (42.8%) without C. trachomatis infection. Our findings showed a distinct compositional difference between the cervical microbiota of C. trachomatis- infected subjects and subjects without C. trachomatis infection. Specifically, significant elevations of mostly strict and facultative anaerobes such as Streptococcus, Megasphaera, Prevotella, and Veillonella in the cervical microbiota of C. trachomatis-positive women were detected. The results from the current study highlights an interaction of C. trachomatis with the environmental microbiome in the endocervical region.

Original languageEnglish
Article numbere0224658
Number of pages16
JournalPLoS ONE
Issue number11
Publication statusPublished - 18 Nov 2019

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