@article{dcaab5937c8e4d1d853c297b0c13ea41,
title = "Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia",
abstract = "The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. In this study, we profiled the cervical microbial composition of a population of 70 reproductive-age Malaysian women; among which 40 (57.1%) were diagnosed with genital C. trachomatis infection, and 30 (42.8%) without C. trachomatis infection. Our findings showed a distinct compositional difference between the cervical microbiota of C. trachomatis- infected subjects and subjects without C. trachomatis infection. Specifically, significant elevations of mostly strict and facultative anaerobes such as Streptococcus, Megasphaera, Prevotella, and Veillonella in the cervical microbiota of C. trachomatis-positive women were detected. The results from the current study highlights an interaction of C. trachomatis with the environmental microbiome in the endocervical region. ",
author = "Cheong, {Heng Choon} and Yap, {Polly Soo Xi} and Chong, {Chun Wie} and Cheok, {Yi Ying} and Lee, {Chalystha Yie Qin} and Tan, {Grace Min Yi} and Sofiah Sulaiman and Jamiyah Hassan and Sabet, {Negar Shafiei} and Looi, {Chung Yeng} and Rishein Gupta and Bernard Arulanandam and Sazaly AbuBakar and Teh, {Cindy Shuan Ju} and Chang, {Li Yen} and Wong, {Won Fen}",
note = "Funding Information: This study was supported by the Fundamental Research Grant Scheme (FP014- 2017A) from the Malaysian Ministry of Education to WFW, and University of Malaya Specialist Center (UMSC) C.A.R.E. Fund (PV061-2018) to SS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2019 Cheong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2019",
month = nov,
day = "18",
doi = "10.1371/journal.pone.0224658",
language = "English",
volume = "14",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science (PLoS)",
number = "11",
}