Diversity among memory B cells: Origin, consequences, and utility

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120 Citations (Scopus)

Abstract

Immunological memory is the residuum of a successful immune response that in the B cell lineage comprises long-lived plasma cells and long-lived memory B cells. It is apparent that distinct classes of memory B cells exist, distinguishable by, among other things, immunoglobulin isotype, location, and passage through the germinal center. Some of this variation is due to the nature of the antigen, and some appears to be inherent to the process of forming memory. Here, we consider the heterogeneity in development and phenotype of memory B cells and whether particular functions are partitioned into distinct subsets. We consider also how understanding the details of generating memory may provide opportunities to develop better, functionally targeted vaccines.
Original languageEnglish
Pages (from-to)1205 - 1211
Number of pages7
JournalScience
Volume341
Issue number6151
DOIs
Publication statusPublished - 2013

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