TY - JOUR
T1 - Divergent ileal IGF-I and IGFBP-3 gene expression after small bowel resection
T2 - a novel mechanism to amplify IGF action?
AU - Albiston, Anthony L.
AU - Taylor, Russell G.
AU - Herington, Adrian C.
AU - Beveridge, Dianne J.
AU - Fuller, Peter J.
PY - 1992
Y1 - 1992
N2 - Changes in the levels of ileal insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) mRNA in the rat following massive small bowel resection (MSBR) have been investigated with a sensitive S1 nuclease assay. IGF-I mRNA levels vary little over 7 days; in contrast IGFBP-3 mRNA levels decreased to one-third 7 h post-MSBR, and remained suppressed for the length of this study. We postulate that decreased ileal synthesis of IGFBP-3 enhances the ability of IGF-I to stimulate the adaptive response.
AB - Changes in the levels of ileal insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) mRNA in the rat following massive small bowel resection (MSBR) have been investigated with a sensitive S1 nuclease assay. IGF-I mRNA levels vary little over 7 days; in contrast IGFBP-3 mRNA levels decreased to one-third 7 h post-MSBR, and remained suppressed for the length of this study. We postulate that decreased ileal synthesis of IGFBP-3 enhances the ability of IGF-I to stimulate the adaptive response.
KW - Insulin-like growth factor
KW - Insulin-like growth factor binding protein-3
KW - Intestinal adaptation
KW - Massive small bowel resection
UR - http://www.scopus.com/inward/record.url?scp=0026565288&partnerID=8YFLogxK
U2 - 10.1016/0303-7207(92)90166-4
DO - 10.1016/0303-7207(92)90166-4
M3 - Article
C2 - 1372273
AN - SCOPUS:0026565288
SN - 0303-7207
VL - 83
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 2-3
ER -