Divergent ileal IGF-I and IGFBP-3 gene expression after small bowel resection: a novel mechanism to amplify IGF action?

Anthony L. Albiston, Russell G. Taylor, Adrian C. Herington, Dianne J. Beveridge, Peter J. Fuller

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36 Citations (Scopus)

Abstract

Changes in the levels of ileal insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) mRNA in the rat following massive small bowel resection (MSBR) have been investigated with a sensitive S1 nuclease assay. IGF-I mRNA levels vary little over 7 days; in contrast IGFBP-3 mRNA levels decreased to one-third 7 h post-MSBR, and remained suppressed for the length of this study. We postulate that decreased ileal synthesis of IGFBP-3 enhances the ability of IGF-I to stimulate the adaptive response.

Original languageEnglish
JournalMolecular and Cellular Endocrinology
Volume83
Issue number2-3
DOIs
Publication statusPublished - 1992
Externally publishedYes

Keywords

  • Insulin-like growth factor
  • Insulin-like growth factor binding protein-3
  • Intestinal adaptation
  • Massive small bowel resection

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