Divergent cell signaling after short-term intensified endurance training in human skeletal muscle

Boubacar Benziane, Timothy John Burton, Brendan Colby Thomas Scanlan, Dana Galuska, Benedict James Canny, Alexander V Chibalin, Juleen R Zierath, Nigel K Stepto

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73 Citations (Scopus)


Endurance training represents one extreme in the continuum of skeletal muscle plasticity. The molecular signals elicited in response to acute and chronic exercise and the integration of multiple intracellular pathways are incompletely understood. We determined the effect of 10-d of intensified cycle training on signal transduction in 9 inactive males in response to a 1h acute bout of cycling at the same absolute workload (164+/-9W). Muscle biopsies were taken at rest, immediately and 3h after the acute exercise. The metabolic signaling pathways including AMPK and mTOR demonstrated divergent regulation by exercise after training. AMPK phosphorylation increased in response to exercise ( 16 fold; P
Original languageEnglish
Pages (from-to)E1427 - E1438
Number of pages12
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number6
Publication statusPublished - 2008

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