Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

Claire Jenkins; Neil T. Perry; Tom Cheasty; Darren J. Shaw; Gad Frankel; Gordon Dougan; George J. Gunn; Henry R. Smith; Adrienne W. Paton; James C. Paton

doi:10.1128/JCM.41.4.1775-1778.2003

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

Claire Jenkins, Neil T. Perry, Tom Cheasty, Darren J. Shaw, Gad Frankel, Gordon Dougan, George J. Gunn, Henry R. Smith, Adrienne W. Paton, James C. Paton

Research output: Contribution to journal › Article › Research › peer-review

75 Citations (Scopus)

Abstract

Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P < 0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).

Original language	English
Pages (from-to)	1775-1778
Number of pages	4
Journal	Journal of Clinical Microbiology
Volume	41
Issue number	4
DOIs	https://doi.org/10.1128/JCM.41.4.1775-1778.2003
Publication status	Published - 1 Apr 2003
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/JCM.41.4.1775-1778.2003

Cite this

@article{52b775617aa844189ad7ab38bcb138b6,

title = "Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins",

abstract = "Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P < 0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).",

author = "Claire Jenkins and Perry, {Neil T.} and Tom Cheasty and Shaw, {Darren J.} and Gad Frankel and Gordon Dougan and Gunn, {George J.} and Smith, {Henry R.} and Paton, {Adrienne W.} and Paton, {James C.}",

year = "2003",

month = apr,

day = "1",

doi = "10.1128/JCM.41.4.1775-1778.2003",

language = "English",

volume = "41",

pages = "1775--1778",

journal = "Journal of Clinical Microbiology",

issn = "0095-1137",

publisher = "American Society for Microbiology",

number = "4",

}

TY - JOUR

T1 - Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

AU - Jenkins, Claire

AU - Perry, Neil T.

AU - Cheasty, Tom

AU - Shaw, Darren J.

AU - Frankel, Gad

AU - Dougan, Gordon

AU - Gunn, George J.

AU - Smith, Henry R.

AU - Paton, Adrienne W.

AU - Paton, James C.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P < 0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).

AB - Certain strains of Shiga toxin-producing Escherichia coli (STEC) which do not have the locus of enterocyte effacement pathogenicity island carry the STEC autoagglutinating adhesin (saa) gene. The distribution of the saa gene in STEC isolates from patients with hemolytic-uremic syndrome (HUS), patients with less severe diarrheal disease, asymptomatic individuals, and healthy cattle was examined. saa-positive strains were detected more frequently (P < 0.001) in STEC strains from bovines (32 of 56 strains) than in those from humans (8 of 91 strains). No significant association (P = 0.135) was found between the saa gene and STEC isolated from patients with HUS (6 of 46 strains) or diarrhea (2 of 29 strains) and from healthy controls (0 of 16 strains).

UR - http://www.scopus.com/inward/record.url?scp=12444268268&partnerID=8YFLogxK

U2 - 10.1128/JCM.41.4.1775-1778.2003

DO - 10.1128/JCM.41.4.1775-1778.2003

M3 - Article

C2 - 12682185

AN - SCOPUS:12444268268

SN - 0095-1137

VL - 41

SP - 1775

EP - 1778

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 4

ER -

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

Abstract

UN SDGs

Access to Document

Other files and links

Cite this