Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies

Stuart Keith Roberts, Joanne Mitchell, Reynold Leung, David Booth, Steven Bollipo, George Ostapowicz, Andrew Sloss, Geoffrey McCaughan, Gregory J Dore, Alexander James V Thompson, Darrell Crawford, William Sievert, Martin D Weltman, Wendy Cheng, Jacob George

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background and Aims: The aim of this study was to examine the distribution of interferon lambda-3 (IFN-?3) gene polymorphisms in previously untreated Australian patients with genotype 1 (Gt1) chronic hepatitis C (CHC) and to compare the IFN-?3 genotype frequency among the different ethnic populations. Methods: This was a prospective, multicenter, observational study undertaken by the Australian Liver Association Clinical Research Network. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment. IFN-?3 single nucleotide polymorphisms were genotyped by the Applied Biosystems s Taqman single nucleotide polymorphism genotyping assay. Results: Between May 2012 and June 2012, 1132 patients were recruited from 38 treatment clinics across Australia. Also, 561 subjects from the CHARIOT (collaborative group hepatitis C study using high dose Pegasys RBV Induction dose in genotype one) study of high-dose interferon who had baseline serum available were retrospectively tested. The overall frequency of IFN-?3 rs12979860 CC/CT/TT genotypes was 36 , 52 , and 12 , and that of rs8099917 TT/TG/GG genotypes was 54 , 41 , and 5 , respectively. The prevalence of the favorable IFN-?3 rs12979860 CC and rs8099917 TT genotypes in Causcasians, Asians, Aboriginals, Maori/Pacific Islanders, and Mediterraneans was 32 and 52 , 80 and 86 , 33 and 63 , 77 and 88 , and 19 and 29 , respectively. Compared with Caucasians, the frequency of IFN-?3 CC was significantly higher among Asians (P
Original languageEnglish
Pages (from-to)179 - 184
Number of pages6
JournalJournal of Gastroenterology and Hepatology
Volume29
Issue number1
DOIs
Publication statusPublished - 2014

Cite this

Roberts, Stuart Keith ; Mitchell, Joanne ; Leung, Reynold ; Booth, David ; Bollipo, Steven ; Ostapowicz, George ; Sloss, Andrew ; McCaughan, Geoffrey ; Dore, Gregory J ; Thompson, Alexander James V ; Crawford, Darrell ; Sievert, William ; Weltman, Martin D ; Cheng, Wendy ; George, Jacob. / Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies. In: Journal of Gastroenterology and Hepatology. 2014 ; Vol. 29, No. 1. pp. 179 - 184.
@article{2be130245b84416fbc626a9f5d20dff5,
title = "Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies",
abstract = "Background and Aims: The aim of this study was to examine the distribution of interferon lambda-3 (IFN-?3) gene polymorphisms in previously untreated Australian patients with genotype 1 (Gt1) chronic hepatitis C (CHC) and to compare the IFN-?3 genotype frequency among the different ethnic populations. Methods: This was a prospective, multicenter, observational study undertaken by the Australian Liver Association Clinical Research Network. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment. IFN-?3 single nucleotide polymorphisms were genotyped by the Applied Biosystems s Taqman single nucleotide polymorphism genotyping assay. Results: Between May 2012 and June 2012, 1132 patients were recruited from 38 treatment clinics across Australia. Also, 561 subjects from the CHARIOT (collaborative group hepatitis C study using high dose Pegasys RBV Induction dose in genotype one) study of high-dose interferon who had baseline serum available were retrospectively tested. The overall frequency of IFN-?3 rs12979860 CC/CT/TT genotypes was 36 , 52 , and 12 , and that of rs8099917 TT/TG/GG genotypes was 54 , 41 , and 5 , respectively. The prevalence of the favorable IFN-?3 rs12979860 CC and rs8099917 TT genotypes in Causcasians, Asians, Aboriginals, Maori/Pacific Islanders, and Mediterraneans was 32 and 52 , 80 and 86 , 33 and 63 , 77 and 88 , and 19 and 29 , respectively. Compared with Caucasians, the frequency of IFN-?3 CC was significantly higher among Asians (P",
author = "Roberts, {Stuart Keith} and Joanne Mitchell and Reynold Leung and David Booth and Steven Bollipo and George Ostapowicz and Andrew Sloss and Geoffrey McCaughan and Dore, {Gregory J} and Thompson, {Alexander James V} and Darrell Crawford and William Sievert and Weltman, {Martin D} and Wendy Cheng and Jacob George",
year = "2014",
doi = "10.1111/jgh.12424",
language = "English",
volume = "29",
pages = "179 -- 184",
journal = "Journal of Gastroenterology and Hepatology",
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Roberts, SK, Mitchell, J, Leung, R, Booth, D, Bollipo, S, Ostapowicz, G, Sloss, A, McCaughan, G, Dore, GJ, Thompson, AJV, Crawford, D, Sievert, W, Weltman, MD, Cheng, W & George, J 2014, 'Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies', Journal of Gastroenterology and Hepatology, vol. 29, no. 1, pp. 179 - 184. https://doi.org/10.1111/jgh.12424

Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies. / Roberts, Stuart Keith; Mitchell, Joanne; Leung, Reynold; Booth, David; Bollipo, Steven; Ostapowicz, George; Sloss, Andrew; McCaughan, Geoffrey; Dore, Gregory J; Thompson, Alexander James V; Crawford, Darrell; Sievert, William; Weltman, Martin D; Cheng, Wendy; George, Jacob.

In: Journal of Gastroenterology and Hepatology, Vol. 29, No. 1, 2014, p. 179 - 184.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies

AU - Roberts, Stuart Keith

AU - Mitchell, Joanne

AU - Leung, Reynold

AU - Booth, David

AU - Bollipo, Steven

AU - Ostapowicz, George

AU - Sloss, Andrew

AU - McCaughan, Geoffrey

AU - Dore, Gregory J

AU - Thompson, Alexander James V

AU - Crawford, Darrell

AU - Sievert, William

AU - Weltman, Martin D

AU - Cheng, Wendy

AU - George, Jacob

PY - 2014

Y1 - 2014

N2 - Background and Aims: The aim of this study was to examine the distribution of interferon lambda-3 (IFN-?3) gene polymorphisms in previously untreated Australian patients with genotype 1 (Gt1) chronic hepatitis C (CHC) and to compare the IFN-?3 genotype frequency among the different ethnic populations. Methods: This was a prospective, multicenter, observational study undertaken by the Australian Liver Association Clinical Research Network. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment. IFN-?3 single nucleotide polymorphisms were genotyped by the Applied Biosystems s Taqman single nucleotide polymorphism genotyping assay. Results: Between May 2012 and June 2012, 1132 patients were recruited from 38 treatment clinics across Australia. Also, 561 subjects from the CHARIOT (collaborative group hepatitis C study using high dose Pegasys RBV Induction dose in genotype one) study of high-dose interferon who had baseline serum available were retrospectively tested. The overall frequency of IFN-?3 rs12979860 CC/CT/TT genotypes was 36 , 52 , and 12 , and that of rs8099917 TT/TG/GG genotypes was 54 , 41 , and 5 , respectively. The prevalence of the favorable IFN-?3 rs12979860 CC and rs8099917 TT genotypes in Causcasians, Asians, Aboriginals, Maori/Pacific Islanders, and Mediterraneans was 32 and 52 , 80 and 86 , 33 and 63 , 77 and 88 , and 19 and 29 , respectively. Compared with Caucasians, the frequency of IFN-?3 CC was significantly higher among Asians (P

AB - Background and Aims: The aim of this study was to examine the distribution of interferon lambda-3 (IFN-?3) gene polymorphisms in previously untreated Australian patients with genotype 1 (Gt1) chronic hepatitis C (CHC) and to compare the IFN-?3 genotype frequency among the different ethnic populations. Methods: This was a prospective, multicenter, observational study undertaken by the Australian Liver Association Clinical Research Network. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment. IFN-?3 single nucleotide polymorphisms were genotyped by the Applied Biosystems s Taqman single nucleotide polymorphism genotyping assay. Results: Between May 2012 and June 2012, 1132 patients were recruited from 38 treatment clinics across Australia. Also, 561 subjects from the CHARIOT (collaborative group hepatitis C study using high dose Pegasys RBV Induction dose in genotype one) study of high-dose interferon who had baseline serum available were retrospectively tested. The overall frequency of IFN-?3 rs12979860 CC/CT/TT genotypes was 36 , 52 , and 12 , and that of rs8099917 TT/TG/GG genotypes was 54 , 41 , and 5 , respectively. The prevalence of the favorable IFN-?3 rs12979860 CC and rs8099917 TT genotypes in Causcasians, Asians, Aboriginals, Maori/Pacific Islanders, and Mediterraneans was 32 and 52 , 80 and 86 , 33 and 63 , 77 and 88 , and 19 and 29 , respectively. Compared with Caucasians, the frequency of IFN-?3 CC was significantly higher among Asians (P

UR - http://onlinelibrary.wiley.com/doi/10.1111/jgh.12424/pdf

U2 - 10.1111/jgh.12424

DO - 10.1111/jgh.12424

M3 - Article

VL - 29

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EP - 184

JO - Journal of Gastroenterology and Hepatology

JF - Journal of Gastroenterology and Hepatology

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