Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies

Stuart Keith Roberts, Joanne Mitchell, Reynold Leung, David Booth, Steven Bollipo, George Ostapowicz, Andrew Sloss, Geoffrey McCaughan, Gregory J Dore, Alexander James V Thompson, Darrell Crawford, William Sievert, Martin D Weltman, Wendy Cheng, Jacob George

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Abstract

Background and Aims: The aim of this study was to examine the distribution of interferon lambda-3 (IFN-?3) gene polymorphisms in previously untreated Australian patients with genotype 1 (Gt1) chronic hepatitis C (CHC) and to compare the IFN-?3 genotype frequency among the different ethnic populations. Methods: This was a prospective, multicenter, observational study undertaken by the Australian Liver Association Clinical Research Network. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment. IFN-?3 single nucleotide polymorphisms were genotyped by the Applied Biosystems s Taqman single nucleotide polymorphism genotyping assay. Results: Between May 2012 and June 2012, 1132 patients were recruited from 38 treatment clinics across Australia. Also, 561 subjects from the CHARIOT (collaborative group hepatitis C study using high dose Pegasys RBV Induction dose in genotype one) study of high-dose interferon who had baseline serum available were retrospectively tested. The overall frequency of IFN-?3 rs12979860 CC/CT/TT genotypes was 36 , 52 , and 12 , and that of rs8099917 TT/TG/GG genotypes was 54 , 41 , and 5 , respectively. The prevalence of the favorable IFN-?3 rs12979860 CC and rs8099917 TT genotypes in Causcasians, Asians, Aboriginals, Maori/Pacific Islanders, and Mediterraneans was 32 and 52 , 80 and 86 , 33 and 63 , 77 and 88 , and 19 and 29 , respectively. Compared with Caucasians, the frequency of IFN-?3 CC was significantly higher among Asians (P
Original languageEnglish
Pages (from-to)179 - 184
Number of pages6
JournalJournal of Gastroenterology and Hepatology
Volume29
Issue number1
DOIs
Publication statusPublished - 2014

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