Distribution of complement C'2 and C'6 types in Australian cases of diabetes mellitus

R. L. Kirk, P. R. Ranford, J. Court, P. Zimmet

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A series of patients with juvenile onset diabetes (IDDM) and mature onset diabetes (NIDDM) have been typed for genetic variants of two sets of complement factors. For the HLA-linked C'2 system, there was found a significant increase of the C'2 2-1 type in IDDM compared with NIDDM patients or healthy controls. No such increase in any phenotype was observed for the non-HLA-linked C'6 system. These observations emphasize again the genetic distinction between IDDM and NIDDM, and the role of chromosome 6 in controlling susceptibility to the insulin-dependent form of the disease.

Original languageEnglish
Pages (from-to)614-615
Number of pages2
JournalMedical Journal of Australia
Issue number11
Publication statusPublished - 1980
Externally publishedYes

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