Distribution of angiotensin converting enzyme in sheep hypothalamus and medulla oblongata visualized by in vitro autoradiography

S. Y. Chai, M. J. Mckinley, F. A.O. Mendelsohn

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13 Citations (Scopus)

Abstract

In vitro autoradiographic mapping of angiotensin converting enzyme (ACE) in sheep brain using the specific ACE inhibitor, 125I-351A, revealed very high densities of binding in large blood vessels and choroid plexus. In the forebrain, a very high density of labelling occurred in the organum vasculosum of the lamina terminalis and median eminence and a high density in the subfornical organ and moderate density in supraoptic, suprachiasmatic, arcuate and paraventricular nuclei. All fiber tracts were unlabelled. In the medulla oblongata, a very high density of binding was detected in the area postrema and a high density in the nucleus of the solitary tract and dorsal motor nucleus of the vagus; a moderate density was found in the substantia gelatinosa of the spinal tract and the inferior olivary nucleus.

Original languageEnglish
Pages (from-to)449-460
Number of pages12
JournalClinical and Experimental Hypertension
VolumeA9
Issue number2-3
DOIs
Publication statusPublished - 1 Jan 1987
Externally publishedYes

Keywords

  • Angiotensin converting enzyme
  • Angiotensin II
  • Autoradiography
  • Blood pressure
  • Brain
  • Circumventricular organs
  • Drinking
  • Hypothalamus
  • Kininase II
  • Medulla oblongata
  • Renin
  • Sheep
  • Vasopressin

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