Abstract
In vitro autoradiographic mapping of angiotensin converting enzyme (ACE) in sheep brain using the specific ACE inhibitor, 125I-351A, revealed very high densities of binding in large blood vessels and choroid plexus. In the forebrain, a very high density of labelling occurred in the organum vasculosum of the lamina terminalis and median eminence and a high density in the subfornical organ and moderate density in supraoptic, suprachiasmatic, arcuate and paraventricular nuclei. All fiber tracts were unlabelled. In the medulla oblongata, a very high density of binding was detected in the area postrema and a high density in the nucleus of the solitary tract and dorsal motor nucleus of the vagus; a moderate density was found in the substantia gelatinosa of the spinal tract and the inferior olivary nucleus.
| Original language | English |
|---|---|
| Pages (from-to) | 449-460 |
| Number of pages | 12 |
| Journal | Clinical and Experimental Hypertension |
| Volume | A9 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 1 Jan 1987 |
| Externally published | Yes |
Keywords
- Angiotensin converting enzyme
- Angiotensin II
- Autoradiography
- Blood pressure
- Brain
- Circumventricular organs
- Drinking
- Hypothalamus
- Kininase II
- Medulla oblongata
- Renin
- Sheep
- Vasopressin
Cite this
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Distribution of angiotensin converting enzyme in sheep hypothalamus and medulla oblongata visualized by in vitro autoradiography. / Chai, S. Y.; Mckinley, M. J.; Mendelsohn, F. A.O.
In: Clinical and Experimental Hypertension, Vol. A9, No. 2-3, 01.01.1987, p. 449-460.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Distribution of angiotensin converting enzyme in sheep hypothalamus and medulla oblongata visualized by in vitro autoradiography
AU - Chai, S. Y.
AU - Mckinley, M. J.
AU - Mendelsohn, F. A.O.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - In vitro autoradiographic mapping of angiotensin converting enzyme (ACE) in sheep brain using the specific ACE inhibitor, 125I-351A, revealed very high densities of binding in large blood vessels and choroid plexus. In the forebrain, a very high density of labelling occurred in the organum vasculosum of the lamina terminalis and median eminence and a high density in the subfornical organ and moderate density in supraoptic, suprachiasmatic, arcuate and paraventricular nuclei. All fiber tracts were unlabelled. In the medulla oblongata, a very high density of binding was detected in the area postrema and a high density in the nucleus of the solitary tract and dorsal motor nucleus of the vagus; a moderate density was found in the substantia gelatinosa of the spinal tract and the inferior olivary nucleus.
AB - In vitro autoradiographic mapping of angiotensin converting enzyme (ACE) in sheep brain using the specific ACE inhibitor, 125I-351A, revealed very high densities of binding in large blood vessels and choroid plexus. In the forebrain, a very high density of labelling occurred in the organum vasculosum of the lamina terminalis and median eminence and a high density in the subfornical organ and moderate density in supraoptic, suprachiasmatic, arcuate and paraventricular nuclei. All fiber tracts were unlabelled. In the medulla oblongata, a very high density of binding was detected in the area postrema and a high density in the nucleus of the solitary tract and dorsal motor nucleus of the vagus; a moderate density was found in the substantia gelatinosa of the spinal tract and the inferior olivary nucleus.
KW - Angiotensin converting enzyme
KW - Angiotensin II
KW - Autoradiography
KW - Blood pressure
KW - Brain
KW - Circumventricular organs
KW - Drinking
KW - Hypothalamus
KW - Kininase II
KW - Medulla oblongata
KW - Renin
KW - Sheep
KW - Vasopressin
UR - http://www.scopus.com/inward/record.url?scp=0023193632&partnerID=8YFLogxK
U2 - 10.3109/10641968709164212
DO - 10.3109/10641968709164212
M3 - Article
VL - A9
SP - 449
EP - 460
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
SN - 0148-3927
IS - 2-3
ER -