Distinguishing Susac’s syndrome from multiple sclerosis

Katherine A. Buzzard, Stephen W. Reddel, Con Yiannikas, D. Sean Riminton, Michael H. Barnett, Todd A. Hardy

Research output: Contribution to journalReview ArticleResearchpeer-review

29 Citations (Scopus)


Susac’s syndrome is considered a rare differential diagnosis in the work-up of suspected multiple sclerosis. Over the last decade or so, significant advances in our understanding of Susac’s syndrome mean that it can now be readily distinguished from multiple sclerosis in the majority of cases with a careful history and close attention to MR imaging. Supporting investigations such as CSF examination, fluorescein angiogram, visual field perimetry and audiology often yield important clues. In milder cases, however, diagnostic uncertainty can exist, and forme frustes of the disease are recognised. In this article, we discuss the clinical features of Susac’s syndrome with emphasis on the findings and investigations that help to differentiate it from MS.

Original languageEnglish
Pages (from-to)1613-1621
Number of pages9
JournalJournal of Neurology
Issue number7
Publication statusPublished - Jul 2015
Externally publishedYes


  • Corpus callosum
  • Demyelination
  • Diagnosis
  • MRI
  • Neuroinflammation
  • Retinocochleocerebral

Cite this