Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis

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Abstract

CD80 and CD86 play a critical role in the initiation of T-cell responses. However, their role in the in vivo effector CD4+ T-cell responses has been less extensively investigated. The current studies have examined the functional relevance of CD80 and CD86 in the effector CD4+ T-cell responses inducing antigen-induced arthritis. Arthritis was induced in C57BL/6 mice by sensitization to methylated bovine serum albumin (mBSA) on day 0, booster immunization (day 7) and intra-articular injection of mBSA (day 21). Control or anti-CD80 and/or anti-CD86 monoclonal antibodies were administered from day 21 to day 28.
Original languageEnglish
Pages (from-to)503 - 513
Number of pages11
JournalImmunology
Volume124
Issue number4
Publication statusPublished - 2008

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