Abstract
Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained.
| Original language | English |
|---|---|
| Pages (from-to) | 291-297 |
| Number of pages | 7 |
| Journal | Journal of Neuropsychology |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 2018 |
Keywords
- Effort
- Methcathinone
- Motivation
- Parkinsonism
- Reward
Cite this
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Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism. / Chong, Trevor T.-J.; Bonnelle, Valerie; Veromann, Kai Riin; Juurmaa, Julius; Taba, Pille; Plant, Olivia; Husain, Masud.
In: Journal of Neuropsychology, Vol. 12, No. 2, 06.2018, p. 291-297.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism
AU - Chong, Trevor T.-J.
AU - Bonnelle, Valerie
AU - Veromann, Kai Riin
AU - Juurmaa, Julius
AU - Taba, Pille
AU - Plant, Olivia
AU - Husain, Masud
PY - 2018/6
Y1 - 2018/6
N2 - Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained.
AB - Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained.
KW - Effort
KW - Methcathinone
KW - Motivation
KW - Parkinsonism
KW - Reward
UR - http://www.scopus.com/inward/record.url?scp=85017340056&partnerID=8YFLogxK
U2 - 10.1111/jnp.12122
DO - 10.1111/jnp.12122
M3 - Article
VL - 12
SP - 291
EP - 297
JO - Journal of Neuropsychology
JF - Journal of Neuropsychology
SN - 1748-6645
IS - 2
ER -