Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism

Trevor T.-J. Chong, Valerie Bonnelle, Kai Riin Veromann, Julius Juurmaa, Pille Taba, Olivia Plant, Masud Husain

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalJournal of Neuropsychology
Volume12
Issue number2
DOIs
Publication statusPublished - Jun 2018

Keywords

  • Effort
  • Methcathinone
  • Motivation
  • Parkinsonism
  • Reward

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