Dissection of B-cell development to unravel defects in patients with a primary antibody deficiency

Mirjam Van Der Burg, Menno C. Van Zelm, Gertjan J A Driessen, Jacques J M Van Dongen

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

11 Citations (Scopus)

Abstract

The cells of the adaptive immune response (B and T lymphocytes) are powerful players in the immune system. Each lymphocyte creates a unique receptor for recognition of pathogens during precursor differentiation in bone marrow or thymus. Together, this results in a large repertoire of antigen receptors with the potential to recognize many different pathogens specifically. On top of this broad repertoire, the lymphocytes that actually recognize antigen are capable of undergoing enormous clonal proliferation, thereby generating huge numbers of daughter cells with the potential to recognize the same pathogen. This clonal expansion generates effector cells for a strong response and long-term memory in the form of memory B and T cells and immunoglobulin (Ig)-producing plasma cells.

Original languageEnglish
Title of host publicationHot Topics in Infection and Immunity in Children VII
EditorsNigel Curtis, Adam Finn, Andrew J. Pollard
Place of PublicationNew York NY USA
PublisherSpringer
Pages183-196
Number of pages14
Volume697
ISBN (Electronic)9781441971852
ISBN (Print)9781441971845
DOIs
Publication statusPublished - 2011
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer
Volume697
ISSN (Print)0065-2598

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