TY - CHAP
T1 - Dissection of B-cell development to unravel defects in patients with a primary antibody deficiency
AU - Van Der Burg, Mirjam
AU - Van Zelm, Menno C.
AU - Driessen, Gertjan J A
AU - Van Dongen, Jacques J M
PY - 2011
Y1 - 2011
N2 - The cells of the adaptive immune response (B and T lymphocytes) are powerful players in the immune system. Each lymphocyte creates a unique receptor for recognition of pathogens during precursor differentiation in bone marrow or thymus. Together, this results in a large repertoire of antigen receptors with the potential to recognize many different pathogens specifically. On top of this broad repertoire, the lymphocytes that actually recognize antigen are capable of undergoing enormous clonal proliferation, thereby generating huge numbers of daughter cells with the potential to recognize the same pathogen. This clonal expansion generates effector cells for a strong response and long-term memory in the form of memory B and T cells and immunoglobulin (Ig)-producing plasma cells.
AB - The cells of the adaptive immune response (B and T lymphocytes) are powerful players in the immune system. Each lymphocyte creates a unique receptor for recognition of pathogens during precursor differentiation in bone marrow or thymus. Together, this results in a large repertoire of antigen receptors with the potential to recognize many different pathogens specifically. On top of this broad repertoire, the lymphocytes that actually recognize antigen are capable of undergoing enormous clonal proliferation, thereby generating huge numbers of daughter cells with the potential to recognize the same pathogen. This clonal expansion generates effector cells for a strong response and long-term memory in the form of memory B and T cells and immunoglobulin (Ig)-producing plasma cells.
UR - http://www.scopus.com/inward/record.url?scp=79952276277&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-7185-2_13
DO - 10.1007/978-1-4419-7185-2_13
M3 - Chapter (Book)
C2 - 21120727
AN - SCOPUS:79952276277
SN - 9781441971845
VL - 697
T3 - Advances in Experimental Medicine and Biology
SP - 183
EP - 196
BT - Hot Topics in Infection and Immunity in Children VII
A2 - Curtis, Nigel
A2 - Finn, Adam
A2 - Pollard, Andrew J.
PB - Springer
CY - New York NY USA
ER -