Abstract
The cells of the adaptive immune response (B and T lymphocytes) are powerful players in the immune system. Each lymphocyte creates a unique receptor for recognition of pathogens during precursor differentiation in bone marrow or thymus. Together, this results in a large repertoire of antigen receptors with the potential to recognize many different pathogens specifically. On top of this broad repertoire, the lymphocytes that actually recognize antigen are capable of undergoing enormous clonal proliferation, thereby generating huge numbers of daughter cells with the potential to recognize the same pathogen. This clonal expansion generates effector cells for a strong response and long-term memory in the form of memory B and T cells and immunoglobulin (Ig)-producing plasma cells.
| Original language | English |
|---|---|
| Title of host publication | Hot Topics in Infection and Immunity in Children VII |
| Editors | Nigel Curtis, Adam Finn, Andrew J. Pollard |
| Place of Publication | New York NY USA |
| Publisher | Springer |
| Pages | 183-196 |
| Number of pages | 14 |
| Volume | 697 |
| ISBN (Electronic) | 9781441971852 |
| ISBN (Print) | 9781441971845 |
| DOIs | |
| Publication status | Published - 2011 |
| Externally published | Yes |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Publisher | Springer |
| Volume | 697 |
| ISSN (Print) | 0065-2598 |
Cite this
}
Dissection of B-cell development to unravel defects in patients with a primary antibody deficiency. / Van Der Burg, Mirjam; Van Zelm, Menno C.; Driessen, Gertjan J A; Van Dongen, Jacques J M.
Hot Topics in Infection and Immunity in Children VII. ed. / Nigel Curtis; Adam Finn; Andrew J. Pollard. Vol. 697 New York NY USA : Springer, 2011. p. 183-196 (Advances in Experimental Medicine and Biology; Vol. 697).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
TY - CHAP
T1 - Dissection of B-cell development to unravel defects in patients with a primary antibody deficiency
AU - Van Der Burg, Mirjam
AU - Van Zelm, Menno C.
AU - Driessen, Gertjan J A
AU - Van Dongen, Jacques J M
PY - 2011
Y1 - 2011
N2 - The cells of the adaptive immune response (B and T lymphocytes) are powerful players in the immune system. Each lymphocyte creates a unique receptor for recognition of pathogens during precursor differentiation in bone marrow or thymus. Together, this results in a large repertoire of antigen receptors with the potential to recognize many different pathogens specifically. On top of this broad repertoire, the lymphocytes that actually recognize antigen are capable of undergoing enormous clonal proliferation, thereby generating huge numbers of daughter cells with the potential to recognize the same pathogen. This clonal expansion generates effector cells for a strong response and long-term memory in the form of memory B and T cells and immunoglobulin (Ig)-producing plasma cells.
AB - The cells of the adaptive immune response (B and T lymphocytes) are powerful players in the immune system. Each lymphocyte creates a unique receptor for recognition of pathogens during precursor differentiation in bone marrow or thymus. Together, this results in a large repertoire of antigen receptors with the potential to recognize many different pathogens specifically. On top of this broad repertoire, the lymphocytes that actually recognize antigen are capable of undergoing enormous clonal proliferation, thereby generating huge numbers of daughter cells with the potential to recognize the same pathogen. This clonal expansion generates effector cells for a strong response and long-term memory in the form of memory B and T cells and immunoglobulin (Ig)-producing plasma cells.
UR - http://www.scopus.com/inward/record.url?scp=79952276277&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-7185-2_13
DO - 10.1007/978-1-4419-7185-2_13
M3 - Chapter (Book)
SN - 9781441971845
VL - 697
T3 - Advances in Experimental Medicine and Biology
SP - 183
EP - 196
BT - Hot Topics in Infection and Immunity in Children VII
A2 - Curtis, Nigel
A2 - Finn, Adam
A2 - Pollard, Andrew J.
PB - Springer
CY - New York NY USA
ER -