Dissection of aberrant GPCR signaling in tumorigenesis - a systems biology approach

Jinhua Wu, Na Xie, Edouard C Nice, Canhua Huang

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

The superfamily of G-protein-coupled receptors (GPCRs) is one of the largest mammalian protein families. It is involved in signal transduction and participates in the regulation of normal physiological function and pathological progression of a range of diseases. Recent studies have demonstrated that many aberrant GPCRs and their ligands are associated with tumorigenesis, angiogenesis and metastasis, which provides promising opportunities for drug discovery for cancer prevention and treatment. It is necessary to search for drug targets such as ligands of unknown GPCRs and better modulators of known GPCRs using high throughput screening approaches. Here, we review recent research advances in the identification of novel GPCRs and their protein interactions.
Original languageEnglish
Pages (from-to)37 - 50
Number of pages14
JournalCancer Genomics and Proteomics
Volume9
Issue number1
Publication statusPublished - 2012

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