Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

Luke E. Formosa, Linden Muellner-Wong, Boris Reljic, Alice J. Sharpe, Thomas D. Jackson, Traude H. Beilharz, Diana Stojanovski, Michael Lazarou, David A. Stroud, Michael T. Ryan

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9 Citations (Scopus)

Abstract

Formosa et al. investigate the function of the MCIA complex in complex I assembly. They demonstrate the requirement of individual components for the formation of complex I intermediates and assembly of the final enzyme. Finally, they characterize the involvement of TMEM186 and COA1 in this process.

Original languageEnglish
Article number107541
Number of pages14
JournalCell Reports
Volume31
Issue number3
DOIs
Publication statusPublished - 21 Apr 2020

Keywords

  • assembly factors
  • complex I
  • MCIA complex
  • mitochondria
  • NADH-ubiquinone dehydrogenase
  • oxidative phosphorylation

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