Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

Luke E. Formosa; Linden Muellner-Wong; Boris Reljic; Alice J. Sharpe; Thomas D. Jackson; Traude H. Beilharz; Diana Stojanovski; Michael Lazarou; David A. Stroud; Michael T. Ryan

doi:10.1016/j.celrep.2020.107541

Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

Luke E. Formosa, Linden Muellner-Wong, Boris Reljic, Alice J. Sharpe, Thomas D. Jackson, Traude H. Beilharz, Diana Stojanovski, Michael Lazarou, David A. Stroud, Michael T. Ryan

Research output: Contribution to journal › Article › Research › peer-review

71 Citations (Scopus)

Abstract

Formosa et al. investigate the function of the MCIA complex in complex I assembly. They demonstrate the requirement of individual components for the formation of complex I intermediates and assembly of the final enzyme. Finally, they characterize the involvement of TMEM186 and COA1 in this process.

Original language	English
Article number	107541
Number of pages	14
Journal	Cell Reports
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2020.107541
Publication status	Published - 21 Apr 2020

Keywords

assembly factors
complex I
MCIA complex
mitochondria
NADH-ubiquinone dehydrogenase
oxidative phosphorylation

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10.1016/j.celrep.2020.107541

303139909-oaFinal published version, 4.07 MB

Cite this

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title = "Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I",

abstract = "Formosa et al. investigate the function of the MCIA complex in complex I assembly. They demonstrate the requirement of individual components for the formation of complex I intermediates and assembly of the final enzyme. Finally, they characterize the involvement of TMEM186 and COA1 in this process.",

keywords = "assembly factors, complex I, MCIA complex, mitochondria, NADH-ubiquinone dehydrogenase, oxidative phosphorylation",

author = "Formosa, {Luke E.} and Linden Muellner-Wong and Boris Reljic and Sharpe, {Alice J.} and Jackson, {Thomas D.} and Beilharz, {Traude H.} and Diana Stojanovski and Michael Lazarou and Stroud, {David A.} and Ryan, {Michael T.}",

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AU - Formosa, Luke E.

AU - Muellner-Wong, Linden

AU - Reljic, Boris

AU - Sharpe, Alice J.

AU - Jackson, Thomas D.

AU - Beilharz, Traude H.

AU - Stojanovski, Diana

AU - Lazarou, Michael

AU - Stroud, David A.

AU - Ryan, Michael T.

PY - 2020/4/21

Y1 - 2020/4/21

N2 - Formosa et al. investigate the function of the MCIA complex in complex I assembly. They demonstrate the requirement of individual components for the formation of complex I intermediates and assembly of the final enzyme. Finally, they characterize the involvement of TMEM186 and COA1 in this process.

AB - Formosa et al. investigate the function of the MCIA complex in complex I assembly. They demonstrate the requirement of individual components for the formation of complex I intermediates and assembly of the final enzyme. Finally, they characterize the involvement of TMEM186 and COA1 in this process.

KW - assembly factors

KW - complex I

KW - MCIA complex

KW - mitochondria

KW - NADH-ubiquinone dehydrogenase

KW - oxidative phosphorylation

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Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

Abstract

Keywords

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Other files and links

Dissecting the functions of accessory subunits in mitochondrial complex I

Systems approaches to understanding the assembly of mitochondrial machines

Systems approaches to understanding mitochondrial function and dysfunction in disease

FlowCore

Monash Proteomics & Metabolomics Facility

Cite this

Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

Abstract

Keywords

Access to Document

Other files and links

Projects

Dissecting the functions of accessory subunits in mitochondrial complex I

Systems approaches to understanding the assembly of mitochondrial machines

Systems approaches to understanding mitochondrial function and dysfunction in disease

Equipment

FlowCore

Monash Proteomics & Metabolomics Facility

Cite this