Dissecting the role of peptides in the immune response: Theory, practice and the application to vaccine design

Anthony W. Purcell, Weiguang Zeng, Nicole A. Mifsud, Lauren K. Ely, Whitney A. Macdonald, David C. Jackson

Research output: Contribution to journalReview ArticleResearchpeer-review

46 Citations (Scopus)

Abstract

Analytical biochemistry and synthetic peptide based chemistry have helped to reveal the pivotal role that peptides play in determining the specificity, magnitude and quality of both humoral (antibody) and cellular (cytotoxic and helper T cell) immune responses. In addition, peptide based technologies are now at the forefront of vaccine design and medical diagnostics. The chemical technologies used to assemble peptides into immunogenic structures have made great strides over the past decade and assembly of highly pure peptides which can be incorporated into high molecular weight species, multimeric and even branched structures together with non-peptidic material is now routine. These structures have a wide range of applications in designer vaccines and diagnostic reagents. Thus the tools of the peptide chemist are exquisitely placed to answer questions about immune recognition and along the way to provide us with new and improved vaccines and diagnostics.

Original languageEnglish
Pages (from-to)255-281
Number of pages27
JournalJournal of Peptide Science
Volume9
Issue number5
DOIs
Publication statusPublished - 1 May 2003
Externally publishedYes

Keywords

  • Antibody
  • Mass spectrometry
  • Peptide synthesis
  • T cells
  • Vaccines

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