Dissecting the apicomplexan rhoptry neck proteins

Nicholas Ian Proellocks, Ross Leon Coppel, Karena Louise Waller

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46 Citations (Scopus)


Apicomplexan parasites possess specialized secretory organelles (rhoptries and micronemes) that release their contents during host cell invasion. Although the rhoptries were once thought to be merely a bulbous protein reservoir connected to an anterior neck region, the localization of a protein specifically to the neck suggested that this region was more than just a duct. Recent studies have shown that the rhoptry neck sub-compartment possesses a distinct protein repertoire. Some of these proteins share common features, including conservation across the phylum and involvement in tight-junction formation. A sub-group of rhoptry neck proteins, the RONs, their association with the microneme protein apical membrane antigen AMA1, and their involvement in invasion are discussed.
Original languageEnglish
Pages (from-to)297 - 304
Number of pages8
JournalTrends in Parasitology
Issue number6
Publication statusPublished - 2010

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