Dissecting the apicomplexan rhoptry neck proteins

Nicholas Ian Proellocks, Ross Leon Coppel, Karena Louise Waller

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Abstract

Apicomplexan parasites possess specialized secretory organelles (rhoptries and micronemes) that release their contents during host cell invasion. Although the rhoptries were once thought to be merely a bulbous protein reservoir connected to an anterior neck region, the localization of a protein specifically to the neck suggested that this region was more than just a duct. Recent studies have shown that the rhoptry neck sub-compartment possesses a distinct protein repertoire. Some of these proteins share common features, including conservation across the phylum and involvement in tight-junction formation. A sub-group of rhoptry neck proteins, the RONs, their association with the microneme protein apical membrane antigen AMA1, and their involvement in invasion are discussed.
Original languageEnglish
Pages (from-to)297 - 304
Number of pages8
JournalTrends in Parasitology
Volume26
Issue number6
DOIs
Publication statusPublished - 2010

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