Dissecting affinity maturation: A model explaining selection of antibody-forming cells and memory B cells in the germinal centre

David M. Tarlinton, Kenneth G.C. Smith

Research output: Contribution to journalComment / DebateOtherpeer-review

113 Citations (Scopus)


Until recently, the relationship between apoptosis, selection in the germinal centre (GC) and production of high-affinity antibody-forming cells (AFCs) and memory B cells has been unclear. Here, Tarlinton and Smith present a model that accounts for the switch in GC production from high-affinity AFCs to memory B cells, and explain how Bcl-2, an inhibitor of apoptosis, can influence memory cells but not bone marrow AFCs.

Original languageEnglish
Pages (from-to)436-441
Number of pages6
JournalImmunology Today
Issue number9
Publication statusPublished - 1 Jan 2000
Externally publishedYes

Cite this