Disruption of the gut microbiome: Clostridium difficile infection and the threat of antibiotic resistance

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Clostridium difficile is well recognized as the leading cause of antibiotic-associated diarrhea, having a significant impact in both health-care and community settings. Central to predisposition to C. difficile infection is disruption of the gut microbiome by antibiotics. Being a Gram-positive anaerobe, C. difficile is intrinsically resistant to a number of antibiotics. Mobile elements encoding antibiotic resistance determinants have also been characterized in this pathogen. While resistance to antibiotics currently used to treat C. difficile infection has not yet been detected, it may be only a matter of time before this occurs, as has been seen with other bacterial pathogens. This review will discuss C. difficile disease pathogenesis, the impact of antibiotic use on inducing disease susceptibility, and the role of antibiotic resistance and mobile elements in C. difficile epidemiology.
Original languageEnglish
Pages (from-to)1347 - 1360
Number of pages14
JournalGenes
Volume6
Issue number4
DOIs
Publication statusPublished - 2015

Cite this

@article{d181ac1cbf954e19a3592c838b537fcc,
title = "Disruption of the gut microbiome: Clostridium difficile infection and the threat of antibiotic resistance",
abstract = "Clostridium difficile is well recognized as the leading cause of antibiotic-associated diarrhea, having a significant impact in both health-care and community settings. Central to predisposition to C. difficile infection is disruption of the gut microbiome by antibiotics. Being a Gram-positive anaerobe, C. difficile is intrinsically resistant to a number of antibiotics. Mobile elements encoding antibiotic resistance determinants have also been characterized in this pathogen. While resistance to antibiotics currently used to treat C. difficile infection has not yet been detected, it may be only a matter of time before this occurs, as has been seen with other bacterial pathogens. This review will discuss C. difficile disease pathogenesis, the impact of antibiotic use on inducing disease susceptibility, and the role of antibiotic resistance and mobile elements in C. difficile epidemiology.",
author = "Johanesen, {Priscilla A} and Mackin, {Kate E} and Hutton, {Melanie L} and Awad, {Milena M} and Sarah Larcombe and Amy, {Jacob M} and Dena Lyras",
year = "2015",
doi = "10.3390/genes6041347",
language = "English",
volume = "6",
pages = "1347 -- 1360",
journal = "Genes",
issn = "2073-4425",
publisher = "MDPI",
number = "4",

}

Disruption of the gut microbiome: Clostridium difficile infection and the threat of antibiotic resistance. / Johanesen, Priscilla A; Mackin, Kate E; Hutton, Melanie L; Awad, Milena M; Larcombe, Sarah; Amy, Jacob M; Lyras, Dena.

In: Genes, Vol. 6, No. 4, 2015, p. 1347 - 1360.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Disruption of the gut microbiome: Clostridium difficile infection and the threat of antibiotic resistance

AU - Johanesen, Priscilla A

AU - Mackin, Kate E

AU - Hutton, Melanie L

AU - Awad, Milena M

AU - Larcombe, Sarah

AU - Amy, Jacob M

AU - Lyras, Dena

PY - 2015

Y1 - 2015

N2 - Clostridium difficile is well recognized as the leading cause of antibiotic-associated diarrhea, having a significant impact in both health-care and community settings. Central to predisposition to C. difficile infection is disruption of the gut microbiome by antibiotics. Being a Gram-positive anaerobe, C. difficile is intrinsically resistant to a number of antibiotics. Mobile elements encoding antibiotic resistance determinants have also been characterized in this pathogen. While resistance to antibiotics currently used to treat C. difficile infection has not yet been detected, it may be only a matter of time before this occurs, as has been seen with other bacterial pathogens. This review will discuss C. difficile disease pathogenesis, the impact of antibiotic use on inducing disease susceptibility, and the role of antibiotic resistance and mobile elements in C. difficile epidemiology.

AB - Clostridium difficile is well recognized as the leading cause of antibiotic-associated diarrhea, having a significant impact in both health-care and community settings. Central to predisposition to C. difficile infection is disruption of the gut microbiome by antibiotics. Being a Gram-positive anaerobe, C. difficile is intrinsically resistant to a number of antibiotics. Mobile elements encoding antibiotic resistance determinants have also been characterized in this pathogen. While resistance to antibiotics currently used to treat C. difficile infection has not yet been detected, it may be only a matter of time before this occurs, as has been seen with other bacterial pathogens. This review will discuss C. difficile disease pathogenesis, the impact of antibiotic use on inducing disease susceptibility, and the role of antibiotic resistance and mobile elements in C. difficile epidemiology.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690045/pdf/genes-06-01347.pdf

U2 - 10.3390/genes6041347

DO - 10.3390/genes6041347

M3 - Article

VL - 6

SP - 1347

EP - 1360

JO - Genes

JF - Genes

SN - 2073-4425

IS - 4

ER -