Disrupted eye movements in preperimetric primary open-angle glaucoma

Raymond P. Najjar, Sourabh Sharma, Morgane Drouet, Stephanie Leruez, Mani Baskaran, Monisha E. Nongpiur, Tin Aung, Joanne Fielding, Owen White, Michael J. Girard, Cédric Lamirel, Dan Milea

Research output: Contribution to journalArticleResearchpeer-review

Abstract

PURPOSE. Primary open-angle glaucoma (POAG) can be associated with abnormal ocular motor behavior, possibly as a compensatory strategy following visual field loss. The aim of this study was to explore the characteristics of saccadic eye movements in patients with early-stage POAG without any detectable glaucomatous visual field loss (i.e., preperimetric POAG). METHODS. Binocular eye movements were explored in 16 patients with bilateral preperimetric POAG and 16 age-matched healthy controls in a cross-sectional, observational study. Visually guided horizontal prosaccades (58, 108, 158, and 208 amplitude) and antisaccades (128 amplitude) were measured using infrared oculography. The latency, average and peak velocities, amplitude and gain of prosaccades as well as the percentage of errors in the antisaccades task were compared between groups. RESULTS. POAG patients exhibited a reduced average velocity of saccades compared to controls across all amplitudes of peripheral visual target presentation (P = 0.03). Saccades performed by POAG patients were hypometric, and with reduced amplitude (P = 0.007) and gain (P = 0.01) compared to controls. On average, POAG patients displayed more antisaccade errors (40.6%), as compared to controls (23.4%; P = 0.04). CONCLUSIONS. Here, we show that patients with POAG without detectable glaucomatous visual field loss exhibit altered saccadic eye movements. These abnormalities may indicate disordered cortical and subcortical saccadic regulation, either on the basis of subthreshold visual impairment, or as a result of wider disease-associated neurodegeneration. Additional studies, controlling for glaucoma medications, are required to delineate the neural basis of eye movement abnormalities associated with POAG.

Original languageEnglish
Pages (from-to)2430-2437
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume58
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017

Keywords

  • Antisaccades
  • Eye movements
  • Infrared oculography
  • Preperimetric
  • Primary open-angle glaucoma
  • Prosaccades

Cite this

Najjar, R. P., Sharma, S., Drouet, M., Leruez, S., Baskaran, M., Nongpiur, M. E., ... Milea, D. (2017). Disrupted eye movements in preperimetric primary open-angle glaucoma. Investigative Ophthalmology and Visual Science, 58(4), 2430-2437. https://doi.org/10.1167/iovs.16-21002
Najjar, Raymond P. ; Sharma, Sourabh ; Drouet, Morgane ; Leruez, Stephanie ; Baskaran, Mani ; Nongpiur, Monisha E. ; Aung, Tin ; Fielding, Joanne ; White, Owen ; Girard, Michael J. ; Lamirel, Cédric ; Milea, Dan. / Disrupted eye movements in preperimetric primary open-angle glaucoma. In: Investigative Ophthalmology and Visual Science. 2017 ; Vol. 58, No. 4. pp. 2430-2437.
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title = "Disrupted eye movements in preperimetric primary open-angle glaucoma",
abstract = "PURPOSE. Primary open-angle glaucoma (POAG) can be associated with abnormal ocular motor behavior, possibly as a compensatory strategy following visual field loss. The aim of this study was to explore the characteristics of saccadic eye movements in patients with early-stage POAG without any detectable glaucomatous visual field loss (i.e., preperimetric POAG). METHODS. Binocular eye movements were explored in 16 patients with bilateral preperimetric POAG and 16 age-matched healthy controls in a cross-sectional, observational study. Visually guided horizontal prosaccades (58, 108, 158, and 208 amplitude) and antisaccades (128 amplitude) were measured using infrared oculography. The latency, average and peak velocities, amplitude and gain of prosaccades as well as the percentage of errors in the antisaccades task were compared between groups. RESULTS. POAG patients exhibited a reduced average velocity of saccades compared to controls across all amplitudes of peripheral visual target presentation (P = 0.03). Saccades performed by POAG patients were hypometric, and with reduced amplitude (P = 0.007) and gain (P = 0.01) compared to controls. On average, POAG patients displayed more antisaccade errors (40.6{\%}), as compared to controls (23.4{\%}; P = 0.04). CONCLUSIONS. Here, we show that patients with POAG without detectable glaucomatous visual field loss exhibit altered saccadic eye movements. These abnormalities may indicate disordered cortical and subcortical saccadic regulation, either on the basis of subthreshold visual impairment, or as a result of wider disease-associated neurodegeneration. Additional studies, controlling for glaucoma medications, are required to delineate the neural basis of eye movement abnormalities associated with POAG.",
keywords = "Antisaccades, Eye movements, Infrared oculography, Preperimetric, Primary open-angle glaucoma, Prosaccades",
author = "Najjar, {Raymond P.} and Sourabh Sharma and Morgane Drouet and Stephanie Leruez and Mani Baskaran and Nongpiur, {Monisha E.} and Tin Aung and Joanne Fielding and Owen White and Girard, {Michael J.} and C{\'e}dric Lamirel and Dan Milea",
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Najjar, RP, Sharma, S, Drouet, M, Leruez, S, Baskaran, M, Nongpiur, ME, Aung, T, Fielding, J, White, O, Girard, MJ, Lamirel, C & Milea, D 2017, 'Disrupted eye movements in preperimetric primary open-angle glaucoma' Investigative Ophthalmology and Visual Science, vol. 58, no. 4, pp. 2430-2437. https://doi.org/10.1167/iovs.16-21002

Disrupted eye movements in preperimetric primary open-angle glaucoma. / Najjar, Raymond P.; Sharma, Sourabh; Drouet, Morgane; Leruez, Stephanie; Baskaran, Mani; Nongpiur, Monisha E.; Aung, Tin; Fielding, Joanne; White, Owen; Girard, Michael J.; Lamirel, Cédric; Milea, Dan.

In: Investigative Ophthalmology and Visual Science, Vol. 58, No. 4, 01.04.2017, p. 2430-2437.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Disrupted eye movements in preperimetric primary open-angle glaucoma

AU - Najjar, Raymond P.

AU - Sharma, Sourabh

AU - Drouet, Morgane

AU - Leruez, Stephanie

AU - Baskaran, Mani

AU - Nongpiur, Monisha E.

AU - Aung, Tin

AU - Fielding, Joanne

AU - White, Owen

AU - Girard, Michael J.

AU - Lamirel, Cédric

AU - Milea, Dan

PY - 2017/4/1

Y1 - 2017/4/1

N2 - PURPOSE. Primary open-angle glaucoma (POAG) can be associated with abnormal ocular motor behavior, possibly as a compensatory strategy following visual field loss. The aim of this study was to explore the characteristics of saccadic eye movements in patients with early-stage POAG without any detectable glaucomatous visual field loss (i.e., preperimetric POAG). METHODS. Binocular eye movements were explored in 16 patients with bilateral preperimetric POAG and 16 age-matched healthy controls in a cross-sectional, observational study. Visually guided horizontal prosaccades (58, 108, 158, and 208 amplitude) and antisaccades (128 amplitude) were measured using infrared oculography. The latency, average and peak velocities, amplitude and gain of prosaccades as well as the percentage of errors in the antisaccades task were compared between groups. RESULTS. POAG patients exhibited a reduced average velocity of saccades compared to controls across all amplitudes of peripheral visual target presentation (P = 0.03). Saccades performed by POAG patients were hypometric, and with reduced amplitude (P = 0.007) and gain (P = 0.01) compared to controls. On average, POAG patients displayed more antisaccade errors (40.6%), as compared to controls (23.4%; P = 0.04). CONCLUSIONS. Here, we show that patients with POAG without detectable glaucomatous visual field loss exhibit altered saccadic eye movements. These abnormalities may indicate disordered cortical and subcortical saccadic regulation, either on the basis of subthreshold visual impairment, or as a result of wider disease-associated neurodegeneration. Additional studies, controlling for glaucoma medications, are required to delineate the neural basis of eye movement abnormalities associated with POAG.

AB - PURPOSE. Primary open-angle glaucoma (POAG) can be associated with abnormal ocular motor behavior, possibly as a compensatory strategy following visual field loss. The aim of this study was to explore the characteristics of saccadic eye movements in patients with early-stage POAG without any detectable glaucomatous visual field loss (i.e., preperimetric POAG). METHODS. Binocular eye movements were explored in 16 patients with bilateral preperimetric POAG and 16 age-matched healthy controls in a cross-sectional, observational study. Visually guided horizontal prosaccades (58, 108, 158, and 208 amplitude) and antisaccades (128 amplitude) were measured using infrared oculography. The latency, average and peak velocities, amplitude and gain of prosaccades as well as the percentage of errors in the antisaccades task were compared between groups. RESULTS. POAG patients exhibited a reduced average velocity of saccades compared to controls across all amplitudes of peripheral visual target presentation (P = 0.03). Saccades performed by POAG patients were hypometric, and with reduced amplitude (P = 0.007) and gain (P = 0.01) compared to controls. On average, POAG patients displayed more antisaccade errors (40.6%), as compared to controls (23.4%; P = 0.04). CONCLUSIONS. Here, we show that patients with POAG without detectable glaucomatous visual field loss exhibit altered saccadic eye movements. These abnormalities may indicate disordered cortical and subcortical saccadic regulation, either on the basis of subthreshold visual impairment, or as a result of wider disease-associated neurodegeneration. Additional studies, controlling for glaucoma medications, are required to delineate the neural basis of eye movement abnormalities associated with POAG.

KW - Antisaccades

KW - Eye movements

KW - Infrared oculography

KW - Preperimetric

KW - Primary open-angle glaucoma

KW - Prosaccades

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U2 - 10.1167/iovs.16-21002

DO - 10.1167/iovs.16-21002

M3 - Article

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SP - 2430

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JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

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Najjar RP, Sharma S, Drouet M, Leruez S, Baskaran M, Nongpiur ME et al. Disrupted eye movements in preperimetric primary open-angle glaucoma. Investigative Ophthalmology and Visual Science. 2017 Apr 1;58(4):2430-2437. https://doi.org/10.1167/iovs.16-21002