Disposition and safety of inhaled biodegradable nanomedicines: opportunities and challenges

Shadabul Haque; Michael R. Whittaker; Michelle P. McIntosh; Colin W. Pouton; Lisa M. Kaminskas

doi:10.1016/j.nano.2016.03.002

Disposition and safety of inhaled biodegradable nanomedicines: opportunities and challenges

Shadabul Haque, Michael R. Whittaker, Michelle P. McIntosh, Colin W. Pouton, Lisa M. Kaminskas

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Review Article › Research › peer-review

76 Citations (Scopus)

Abstract

The inhaled delivery of nanomedicines can provide a novel, non-invasive therapeutic strategy for the more localised treatment of lung-resident diseases and potentially also enable the systemic delivery of therapeutics that are otherwise administered via injection alone. However, the clinical translation of inhalable nanomedicine is being hampered by our lack of understanding about their disposition and clearance from the lungs. This review provides a comprehensive overview of the biodegradable nanomaterials that are currently being explored as inhalable drug delivery systems and our current understanding of their disposition within, and clearance from the lungs. The safety of biodegradable nanomaterials in the lungs is discussed and latest updates are provided on the impact of inflammation on the pulmonary pharmacokinetics of inhaled nanomaterials. Overall, the review provides an in-depth and critical assessment of the lung clearance mechanisms for inhaled biodegradable nanomedicines and highlights the opportunities and challenges for their translation into the clinic.

Original language	English
Pages (from-to)	1703-1724
Number of pages	22
Journal	Nanomedicine: Nanotechnology, Biology and Medicine
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.nano.2016.03.002
Publication status	Published - 1 Aug 2016

Keywords

Biodegradable
Clearance
Drug delivery
Inhalation
Nanomedicine
Pulmonary

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10.1016/j.nano.2016.03.002

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abstract = "The inhaled delivery of nanomedicines can provide a novel, non-invasive therapeutic strategy for the more localised treatment of lung-resident diseases and potentially also enable the systemic delivery of therapeutics that are otherwise administered via injection alone. However, the clinical translation of inhalable nanomedicine is being hampered by our lack of understanding about their disposition and clearance from the lungs. This review provides a comprehensive overview of the biodegradable nanomaterials that are currently being explored as inhalable drug delivery systems and our current understanding of their disposition within, and clearance from the lungs. The safety of biodegradable nanomaterials in the lungs is discussed and latest updates are provided on the impact of inflammation on the pulmonary pharmacokinetics of inhaled nanomaterials. Overall, the review provides an in-depth and critical assessment of the lung clearance mechanisms for inhaled biodegradable nanomedicines and highlights the opportunities and challenges for their translation into the clinic.",

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AU - Pouton, Colin W.

AU - Kaminskas, Lisa M.

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Disposition and safety of inhaled biodegradable nanomedicines: opportunities and challenges

Abstract

Keywords

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ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Improving cancer survival by optimising drug exposure at sites of cancer metastasis

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Disposition and safety of inhaled biodegradable nanomedicines: opportunities and challenges

Abstract

Keywords

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Projects

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Improving cancer survival by optimising drug exposure at sites of cancer metastasis

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