TY - JOUR
T1 - Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity
AU - Pearce, Karma
AU - Hatzinikolas, Alicia
AU - Moran, Lisa
AU - de Courten, Maximilian P J
AU - Forbes, Josephine
AU - Scheijen, Jean L.J.M.
AU - Schalkwijk, Casper G
AU - Walker, Karen
AU - de Courten, Barbora
PY - 2017
Y1 - 2017
N2 - We have previously shown that an isoenergetic low advanced glycation end products (AGEs) diet matched for macronutrient content improved insulin sensitivity compared to high AGE diet. Here, we evaluated the differences in micronutrient intake of these two dietary patterns and if they could explain differences in insulin sensitivity. Participants consumed the intervention diets each for 2 weeks with 4 weeks of habitual dietary intake (washout) in-between. Dietary analysis revealed that the high AGE diet contained greater levels of retinol equivalents (RE) (478.9 + 151.3 μg/day versus 329.0 + 170.0 μg/day; p < .006), vitamin A (806.3 + 223.5 (μg RE)/day versus 649.1 + 235.8 (μg RE)/day; p < .05) and thiamine (2.3 + 0.6 mg/day versus 1.6 + 0.4 mg/day; p = .014) compared to the low AGE diet. The changes in polyunsaturated fat, retinol, vitamin A and thiamine did not correlate with changes in insulin sensitivity (all p > .1) therefore are unlikely to explain observed changes in insulin sensitivity. (clinicaltrials.gov:NCT00422253).
AB - We have previously shown that an isoenergetic low advanced glycation end products (AGEs) diet matched for macronutrient content improved insulin sensitivity compared to high AGE diet. Here, we evaluated the differences in micronutrient intake of these two dietary patterns and if they could explain differences in insulin sensitivity. Participants consumed the intervention diets each for 2 weeks with 4 weeks of habitual dietary intake (washout) in-between. Dietary analysis revealed that the high AGE diet contained greater levels of retinol equivalents (RE) (478.9 + 151.3 μg/day versus 329.0 + 170.0 μg/day; p < .006), vitamin A (806.3 + 223.5 (μg RE)/day versus 649.1 + 235.8 (μg RE)/day; p < .05) and thiamine (2.3 + 0.6 mg/day versus 1.6 + 0.4 mg/day; p = .014) compared to the low AGE diet. The changes in polyunsaturated fat, retinol, vitamin A and thiamine did not correlate with changes in insulin sensitivity (all p > .1) therefore are unlikely to explain observed changes in insulin sensitivity. (clinicaltrials.gov:NCT00422253).
KW - Advanced glycation end products (AGEs)
KW - ageing
KW - chronic disease
KW - lifestyle disease
UR - http://www.scopus.com/inward/record.url?scp=85018423699&partnerID=8YFLogxK
U2 - 10.1080/09637486.2017.1319468
DO - 10.1080/09637486.2017.1319468
M3 - Article
AN - SCOPUS:85018423699
SN - 0963-7486
SP - 1
EP - 6
JO - International Journal of Food Sciences and Nutrition
JF - International Journal of Food Sciences and Nutrition
ER -