DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism

Martina Zikova, Alicia Corlett, Zdenka Bendova, Petr Pajer, Petr Bartunek

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

In the body, the brain is the most cholesterol-rich organ. Despite this, remarkably little is known about the mechanisms in the brain that regulate cholesterol homeostasis. Due to the blood-brain barrier, plasma lipoproteins are unable to traverse, and instead cholesterol must be synthesized de novo from within the central nervous system. Thyroid hormone receptors, activated in response to thyroid hormone (T3), are known to modulate the level of serum cholesterol via complex regulatory pathways. By screening for T3-regulated genes we have identified Disp3, a sterol-sensing domain-containing protein that is related to the Dispatched family of proteins. Analysis by RT-PCR and immunohistochemistry demonstrated that DISP3 is predominately expressed in specific cell types of the brain, retina, and testis. Using the model of hyperthyroidism in vivo, we observed the modulation of Disp3 expression in the retina. Furthermore, in vitro analysis of Disp3.....
Original languageEnglish
Pages (from-to)520 - 528
Number of pages9
JournalMolecular Endocrinology
Volume23
Issue number4
DOIs
Publication statusPublished - 2009
Externally publishedYes

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