TY - JOUR
T1 - Disease status, patient quality of life and healthcare resource use for ulcerative colitis in the UK
T2 - an observational study
AU - Vaizey, Carolynne J
AU - Gibson, Peter R
AU - Black, Christopher M
AU - Nicholls, Rebecca J
AU - Weston, Adele R
AU - Gaya, Daniel R
AU - Sebastian, Shaji
AU - Shaw, Ian
AU - Lewis, Stephen J.G.
AU - Bloom, Stuart
AU - Gordon, John N
AU - Beale, Amanda
AU - Arnott, Ian
AU - Campbell, Simon
AU - Fan, Tao
PY - 2014
Y1 - 2014
N2 - Background Ulcerative colitis is a lifelong, chronic, relapsing-remitting disease.
Objective To assess the relationship between ulcerative colitis disease status and patient quality of life, and to determine the impact of ulcerative colitis on healthcare costs and work productivity, in the UK.
Methods Clinicians assessed 173 adult patients’ current disease status at a single study visit using the partial Mayo (pMayo) instrument. Patients completed the Euro Quality of Life 5-dimension, 5-level (EQ-5D-5L) questionnaire, the Work Productivity and Activity Impairment (WPAI) questionnaire. Healthcare resource use was determined from questionnaires and from patients’ medical charts.
Results Patients in remission had a significantly higher EQ-5D-5L scores (mean (SD) 0.86 (0.15)) than patients with active disease (0.71 (0.20); p<0.001). Patients with mild disease had significantly higher mean (SD) EQ-5D-5L scores than patients with moderate/severe disease: 0.77 (0.11) and 0.66 (0.24), respectively (p<0.001). The mean percent productivity impairment was greater for patients with active disease than for patients in remission on all items of the WPAI questionnaire: 24.6% vs 1.8% for work time missed, 34.1% vs 12.9% for impairment while working, 40.8% vs 14.4% for overall work impairment and 42.7% vs 13.0% for activity impairment (p<0.001 for all comparisons). The mean (SD) total cost of healthcare for ulcerative colitis in the prior 3 months was £1211 (1588).
Conclusions When compared with patients in remission, patients with active ulcerative colitis have significantly worse quality of life and significantly more work impairment. The healthcare costs of ulcerative colitis are considerable.
AB - Background Ulcerative colitis is a lifelong, chronic, relapsing-remitting disease.
Objective To assess the relationship between ulcerative colitis disease status and patient quality of life, and to determine the impact of ulcerative colitis on healthcare costs and work productivity, in the UK.
Methods Clinicians assessed 173 adult patients’ current disease status at a single study visit using the partial Mayo (pMayo) instrument. Patients completed the Euro Quality of Life 5-dimension, 5-level (EQ-5D-5L) questionnaire, the Work Productivity and Activity Impairment (WPAI) questionnaire. Healthcare resource use was determined from questionnaires and from patients’ medical charts.
Results Patients in remission had a significantly higher EQ-5D-5L scores (mean (SD) 0.86 (0.15)) than patients with active disease (0.71 (0.20); p<0.001). Patients with mild disease had significantly higher mean (SD) EQ-5D-5L scores than patients with moderate/severe disease: 0.77 (0.11) and 0.66 (0.24), respectively (p<0.001). The mean percent productivity impairment was greater for patients with active disease than for patients in remission on all items of the WPAI questionnaire: 24.6% vs 1.8% for work time missed, 34.1% vs 12.9% for impairment while working, 40.8% vs 14.4% for overall work impairment and 42.7% vs 13.0% for activity impairment (p<0.001 for all comparisons). The mean (SD) total cost of healthcare for ulcerative colitis in the prior 3 months was £1211 (1588).
Conclusions When compared with patients in remission, patients with active ulcerative colitis have significantly worse quality of life and significantly more work impairment. The healthcare costs of ulcerative colitis are considerable.
U2 - 10.1136/flgastro-2013-100409
DO - 10.1136/flgastro-2013-100409
M3 - Article
SN - 2041-4137
VL - 5
SP - 183
EP - 189
JO - Frontline Gastroenterology
JF - Frontline Gastroenterology
IS - 3
ER -