Discrete stimulatory effects of platelet-derived growth factor (PDGF-BB) on Leydig cell steroidogenesis

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Abstract

The effect of platelet-derived growth factor-BB on adult rat Leydig cell steroidogenesis has been determined using culture conditions which maintain testosterone production and responsiveness to luteinising hormone for 3 days. A significant stimulation of testosterone levels was observed in acute response to a maximally stimulating dose (8 ng/ml) of rat luteinising hormone on the third day of culture, but was dependent on pre-exposure of the Leydig cells to PDGF-BB for 2 days, whilst maintained in the presence of a minimum dose (0.1 ng/ml) of rat luteinising hormone. These data demonstrate a very discrete action of PDGF-BB on adult rat Leydig cell steroidogenesis in vitro, but whether or not this constitutes a significant paracrine effect in vivo remains to be established.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalMolecular and Cellular Endocrinology
Volume97
Issue number1-2
DOIs
Publication statusPublished - 1993

Keywords

  • (PDGF-BB)
  • Leydig cells
  • Platelet-derived growth factor-BB
  • Testosterone

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