Discrete modelling of powder dispersion in dry powder inhalers - a brief review

Zhenbo Tong, Aibing Yu, Hak-Kim Chan, Runyu Yang

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Abstract

The performance of a dry powder inhaler (DPI) depends on powder properties as well as the air and particle flows in the device. The main principle of powder dispersion is to overcome the inter-particle cohesion using various dispersion/
de-agglomeration forces. While different dispersion mechanisms have been identified, their relative importance under different conditions is less clear. The lack of understanding of these mechanisms is a major obstacle to the advance
of pharmaceutical powder aerosol technology. This paper briefly reviews our recent effort in developing a combined computational fluid dynamics (CFD) and discrete element method (DEM) approach to gain such pivotal information.
Dispersions under various specifically designed conditions were simulated to exam the role of individual dispersion mechanism. The air and
particle flows were analysed at the particle scale and linked to dispersion performance characterised by fine particle fraction (FPF). In addition,
the dispersion mechanisms of both drug only and carrier based formulations in a commercial inhaler were studied. Our work shows that the approach
has the potential to develop a theoretical framework for designing new DPIs.
Original languageEnglish
Pages (from-to)3966 - 3973
Number of pages8
JournalCurrent Pharmaceutical Design
Volume21
Issue number27
DOIs
Publication statusPublished - 2015

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