Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)

Abdelselam Ali, Marianne Bliese, Jo Anne M Rasmussen, Roger M. Sargent, Simon Saubern, David G. Sawutz, John S. Wilkie, David A. Winkler, Kevin N. Winzenberg, Ruth C J Woodgate

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16 Citations (Scopus)

Abstract

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites. 

Original languageEnglish
Pages (from-to)993-997
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number4
DOIs
Publication statusPublished - 15 Feb 2007
Externally publishedYes

Keywords

  • (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile
  • Ctenocephalides felis (cat flea)
  • Haemonchus contortus
  • Parasiticide

Cite this

Ali, A., Bliese, M., Rasmussen, J. A. M., Sargent, R. M., Saubern, S., Sawutz, D. G., Wilkie, J. S., Winkler, D. A., Winzenberg, K. N., & Woodgate, R. C. J. (2007). Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea). Bioorganic and Medicinal Chemistry Letters, 17(4), 993-997. https://doi.org/10.1016/j.bmcl.2006.11.043