Discovery of retroviral homologs in bats: implications for the origin of mammalian gammaretroviruses

Jie Cui, Mary Tachedjian, Lina Wang, Gilda Tachedjian, Lin-Fa Wang, Shuyi Zhang

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Abstract

Gammaretroviruses infect a wide range of vertebrate species where they are associated with leukemias, neurological diseases and immunodeficiencies. However, the origin of these infectious agents is unknown. Through a phylogenetic analysis of viral gene sequences, we show that bats harbor an especially diverse set of gammaretroviruses. In particular, phylogenetic analysis places Rhinolophus ferrumequinum retrovirus (RfRV), a new gammaretrovirus identified by de novo analysis of the Rhinolophus ferrumequinum transcriptome, and six other gammaretroviruses from different bat species, as basal to other mammalian gammaretroviruses. An analysis of the similarity in the phylogenetic history between the gammaretroviruses and their bat hosts provided evidence for both host-virus codivergence and cross-species transmission. Taken together, these data provide new insights into the origin of the mammalian gammaretroviruses.
Original languageEnglish
Pages (from-to)4288 - 4293
Number of pages6
JournalJournal of Virology
Volume86
Issue number8
DOIs
Publication statusPublished - 2012

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