TY - JOUR
T1 - Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration
AU - Vallieres, Cindy
AU - Hook, Andrew
AU - He, Yinfeng
AU - Cuzzucoli Crucitti, Valentina
AU - Figueredo, Grazziela P.
AU - Davies, Catheryn R
AU - Burroughs, Laurence
AU - Winkler, David A.
AU - Wildman, Ricky D.
AU - Irvine, Derek
AU - Alexander, Morgan R
AU - Avery, Simon V.
PY - 2020/6/5
Y1 - 2020/6/5
N2 - Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passively (i.e., no killing effect). We screened hundreds of (meth)acrylate polymers in high throughput, identifying several that reduce attachment of the human pathogen Candida albicans, the crop pathogen Botrytis cinerea, and other fungi. Specific polymer functional groups were associated with weak attachment. Low fungal colonization materials were not toxic, supporting their passive, anti-attachment utility. We developed a candidate monomer formulation for inkjet-based 3D printing. Printed voice prosthesis components showed up to 100% reduction in C. albicans biofilm versus commercial materials. Furthermore, spray-coated leaf surfaces resisted fungal infection, with no plant toxicity. This is the first high-throughput study of polymer chemistries resisting fungal attachment. These materials are ready for incorporation in products to counteract fungal deterioration of goods, food security, and health.
AB - Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passively (i.e., no killing effect). We screened hundreds of (meth)acrylate polymers in high throughput, identifying several that reduce attachment of the human pathogen Candida albicans, the crop pathogen Botrytis cinerea, and other fungi. Specific polymer functional groups were associated with weak attachment. Low fungal colonization materials were not toxic, supporting their passive, anti-attachment utility. We developed a candidate monomer formulation for inkjet-based 3D printing. Printed voice prosthesis components showed up to 100% reduction in C. albicans biofilm versus commercial materials. Furthermore, spray-coated leaf surfaces resisted fungal infection, with no plant toxicity. This is the first high-throughput study of polymer chemistries resisting fungal attachment. These materials are ready for incorporation in products to counteract fungal deterioration of goods, food security, and health.
UR - http://www.scopus.com/inward/record.url?scp=85086632747&partnerID=8YFLogxK
U2 - 10.1126/sciadv.aba6574
DO - 10.1126/sciadv.aba6574
M3 - Article
C2 - 32548270
AN - SCOPUS:85086632747
SN - 2375-2548
VL - 6
JO - Science Advances
JF - Science Advances
IS - 23
M1 - eaba6574
ER -