Discovery of CYT997: a structurally novel orally active microtubule targeting agent

Christopher Burns, Michael Harte, Xianyong Bu, Emmanuelle Fantino, Max Joffe, Harrison Sikanyika, Stephen Su, C Elisabet Tranberg, Neil Wilson, Susan Ann Charman, David Shackleford, Andrew Frederick Wilks

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)


CYT997 was discovered as a potent tubulin polymerization possessing potent cytotoxic activity against a range of cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 are reported.
Original languageEnglish
Pages (from-to)4639 - 4642
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number16
Publication statusPublished - 2009

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