Discovery of 2-(2-Benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu 5): from an artificial neural network virtual screen to an in vivo tool compound

Ralf Mueller; Eric S Dawson; Jens Meiler; Alice L Rodriguez; Brian A Chauder; Brittney S Bates; Andrew S Felts; Jeffrey P Lamb; Usha N Menon; Sataywan B Jadhav; Alexander S Kane; Carrie K Jones; Karen Joan Gregory; Colleen M Niswender; Peter Jeffrey Conn; Cnristopher M Olsen; Danny G Winder; Kyle A Emmitte; Craig W Lindsley

doi:10.1002/cmdc.201100510

Discovery of 2-(2-Benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu 5): from an artificial neural network virtual screen to an in vivo tool compound

Ralf Mueller
, Eric S Dawson
, Jens Meiler
, Alice L Rodriguez
, Brian A Chauder
, Brittney S Bates
, Andrew S Felts
, Jeffrey P Lamb
, Usha N Menon
, Sataywan B Jadhav
, Alexander S Kane
, Carrie K Jones
, Karen Joan Gregory
, Colleen M Niswender
, Peter Jeffrey Conn
, Cnristopher M Olsen
, Danny G Winder
, Kyle A Emmitte
, Craig W Lindsley

Drug Discovery Biology

Research output: Contribution to journal › Article › Research › peer-review

41 Citations (Scopus)

Original language	English
Pages (from-to)	406 - 414
Number of pages	9
Journal	ChemMedChem
Volume	7
Issue number	3
DOIs	https://doi.org/10.1002/cmdc.201100510
Publication status	Published - 2012

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10.1002/cmdc.201100510

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Mueller, R., Dawson, E. S., Meiler, J., Rodriguez, A. L., Chauder, B. A., Bates, B. S., Felts, A. S., Lamb, J. P., Menon, U. N., Jadhav, S. B., Kane, A. S., Jones, C. K., Gregory, K. J., Niswender, C. M., Conn, P. J., Olsen, C. M., Winder, D. G., Emmitte, K. A., & Lindsley, C. W. (2012). Discovery of 2-(2-Benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu 5): from an artificial neural network virtual screen to an in vivo tool compound. ChemMedChem, 7(3), 406 - 414. https://doi.org/10.1002/cmdc.201100510

@article{3380b37f6c40459aa8cfeec3edd7a855,

title = "Discovery of 2-(2-Benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu 5): from an artificial neural network virtual screen to an in vivo tool compound",

author = "Ralf Mueller and Dawson, \{Eric S\} and Jens Meiler and Rodriguez, \{Alice L\} and Chauder, \{Brian A\} and Bates, \{Brittney S\} and Felts, \{Andrew S\} and Lamb, \{Jeffrey P\} and Menon, \{Usha N\} and Jadhav, \{Sataywan B\} and Kane, \{Alexander S\} and Jones, \{Carrie K\} and Gregory, \{Karen Joan\} and Niswender, \{Colleen M\} and Conn, \{Peter Jeffrey\} and Olsen, \{Cnristopher M\} and Winder, \{Danny G\} and Emmitte, \{Kyle A\} and Lindsley, \{Craig W\}",

year = "2012",

doi = "10.1002/cmdc.201100510",

language = "English",

volume = "7",

pages = "406 -- 414",

journal = "ChemMedChem",

issn = "1860-7179",

publisher = "Wiley-VCH Verlag GmbH \& Co. KGaA",

number = "3",

}

Mueller, R, Dawson, ES, Meiler, J, Rodriguez, AL, Chauder, BA, Bates, BS, Felts, AS, Lamb, JP, Menon, UN, Jadhav, SB, Kane, AS, Jones, CK, Gregory, KJ, Niswender, CM, Conn, PJ, Olsen, CM, Winder, DG, Emmitte, KA & Lindsley, CW 2012, 'Discovery of 2-(2-Benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu 5): from an artificial neural network virtual screen to an in vivo tool compound', ChemMedChem, vol. 7, no. 3, pp. 406 - 414. https://doi.org/10.1002/cmdc.201100510

Discovery of 2-(2-Benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu 5): from an artificial neural network virtual screen to an in vivo tool compound. / Mueller, Ralf; Dawson, Eric S; Meiler, Jens et al.
In: ChemMedChem, Vol. 7, No. 3, 2012, p. 406 - 414.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Discovery of 2-(2-Benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu 5): from an artificial neural network virtual screen to an in vivo tool compound

AU - Mueller, Ralf

AU - Dawson, Eric S

AU - Meiler, Jens

AU - Rodriguez, Alice L

AU - Chauder, Brian A

AU - Bates, Brittney S

AU - Felts, Andrew S

AU - Lamb, Jeffrey P

AU - Menon, Usha N

AU - Jadhav, Sataywan B

AU - Kane, Alexander S

AU - Jones, Carrie K

AU - Gregory, Karen Joan

AU - Niswender, Colleen M

AU - Conn, Peter Jeffrey

AU - Olsen, Cnristopher M

AU - Winder, Danny G

AU - Emmitte, Kyle A

AU - Lindsley, Craig W

PY - 2012

Y1 - 2012

UR - http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201100510/abstract

U2 - 10.1002/cmdc.201100510

DO - 10.1002/cmdc.201100510

M3 - Article

SN - 1860-7179

VL - 7

SP - 406

EP - 414

JO - ChemMedChem

JF - ChemMedChem

IS - 3

ER -

Discovery of 2-(2-Benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu 5): from an artificial neural network virtual screen to an in vivo tool compound

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