Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Christopher J Burns; Michael F. Harte; Xianyong Bu; Emmanuelle Fantino; Marilena Giarrusso; Max Joffe; Margarita Kurek; Fiona Sue Legge; Pasquale Razzino; Stephen Su; Herbert Treutlein; Soo San Wan; Jun Zeng; Andrew F. Wilks

doi:10.1016/j.bmcl.2008.12.073

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Christopher J Burns, Michael F. Harte, Xianyong Bu, Emmanuelle Fantino, Marilena Giarrusso, Max Joffe, Margarita Kurek, Fiona Sue Legge, Pasquale Razzino, Stephen Su, Herbert Treutlein, Soo San Wan, Jun Zeng, Andrew F. Wilks

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.

Original language	English
Pages (from-to)	1206-1209
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2008.12.073
Publication status	Published - 15 Feb 2009
Externally published	Yes

Keywords

CSF-1
CSF-1R
FMS
Kinase inhibitor
M-CSF-1
Macrophage

Access to Document

10.1016/j.bmcl.2008.12.073

Link to publication in Scopus

Cite this

Burns, C. J., Harte, M. F., Bu, X., Fantino, E., Giarrusso, M., Joffe, M., Kurek, M., Legge, F. S., Razzino, P., Su, S., Treutlein, H., Wan, S. S., Zeng, J., & Wilks, A. F. (2009). Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS. Bioorganic and Medicinal Chemistry Letters, 19(4), 1206-1209. https://doi.org/10.1016/j.bmcl.2008.12.073

Burns, Christopher J ; Harte, Michael F. ; Bu, Xianyong ; Fantino, Emmanuelle ; Giarrusso, Marilena ; Joffe, Max ; Kurek, Margarita ; Legge, Fiona Sue ; Razzino, Pasquale ; Su, Stephen ; Treutlein, Herbert ; Wan, Soo San ; Zeng, Jun ; Wilks, Andrew F. / Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 4. pp. 1206-1209.

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abstract = "A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.",

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Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS. / Burns, Christopher J; Harte, Michael F.; Bu, Xianyong; Fantino, Emmanuelle; Giarrusso, Marilena; Joffe, Max; Kurek, Margarita; Legge, Fiona Sue; Razzino, Pasquale; Su, Stephen; Treutlein, Herbert; Wan, Soo San; Zeng, Jun; Wilks, Andrew F.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 4, 15.02.2009, p. 1206-1209.

Research output: Contribution to journal › Article › Research › peer-review

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