Abstract
A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.
Original language | English |
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Pages (from-to) | 1206-1209 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 4 |
DOIs | |
Publication status | Published - 15 Feb 2009 |
Externally published | Yes |
Keywords
- CSF-1
- CSF-1R
- FMS
- Kinase inhibitor
- M-CSF-1
- Macrophage