Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Christopher J Burns, Michael F. Harte, Xianyong Bu, Emmanuelle Fantino, Marilena Giarrusso, Max Joffe, Margarita Kurek, Fiona Sue Legge, Pasquale Razzino, Stephen Su, Herbert Treutlein, Soo San Wan, Jun Zeng, Andrew F. Wilks

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14 Citations (Scopus)

Abstract

A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.

Original languageEnglish
Pages (from-to)1206-1209
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number4
DOIs
Publication statusPublished - 15 Feb 2009
Externally publishedYes

Keywords

  • CSF-1
  • CSF-1R
  • FMS
  • Kinase inhibitor
  • M-CSF-1
  • Macrophage

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