Directed growth of pure phosphatidylcholine nanotubes in microfluidic channels

Ksenia Brazhnik, Wyatt Vreeland, J Hutchison, Rani Kishore, Jeffrey Wells, Kristian Helmerson, L Locascio

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)


The morphology of self-assembled phospholipid membranes (e.g., micelles, vesicles, rods, tubes, etc.) depends on the method of formation, secondary manipulation, temperature, and storage conditions. In this contribution, microfluidic systems are used to create pure phosphatidylcholine (PC) micro- and nanotubes with unprecedented lengths. Tubes up to several centimeters in length and aligned with the long axis of the microchannel were created from spots of dry films of 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC).
Original languageEnglish
Pages (from-to)10814 - 10817
Number of pages4
Issue number23
Publication statusPublished - 2005
Externally publishedYes

Cite this