Direct AT{2} receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice

Sonja Tesanovic Kljajic, Robert Edward Widdop, Antony Vinh, Iresha Kumudu Welungoda, Sanja Bosnyak, Emma Susan Jones, Tracey Ann Gaspari

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20 Citations (Scopus)

Abstract

BACKGROUND: The angiotensin II type 2 receptor (AT(2)R) has been suggested to have an athero-protective role, however no studies have investigated the effect of direct stimulation of this receptor in atherosclerosis. Thus this study aimed to determine the effect of direct AT(2)R stimulation in setting of atherosclerosis, using the known AT(2)R agonist, CGP42112. METHODS AND RESULTS: Apolipoprotein E-deficient (ApoE(-/-)) mice were fed a high fat (21 ) diet for 16 weeks, with subcutaneous infusions of CGP42112 (1, 5 or 10 mug/kg/min) administered via osmotic mini-pumps in the final 4 weeks. CGP42112 treatment at all doses significantly improved endothelial function (p
Original languageEnglish
Pages (from-to)281 - 287
Number of pages7
JournalInternational Journal of Cardiology
Volume169
Issue number4
DOIs
Publication statusPublished - 2013

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