Direct AT{2} receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice

Sonja Tesanovic Kljajic, Robert Edward Widdop, Antony Vinh, Iresha Kumudu Welungoda, Sanja Bosnyak, Emma Susan Jones, Tracey Ann Gaspari

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND: The angiotensin II type 2 receptor (AT(2)R) has been suggested to have an athero-protective role, however no studies have investigated the effect of direct stimulation of this receptor in atherosclerosis. Thus this study aimed to determine the effect of direct AT(2)R stimulation in setting of atherosclerosis, using the known AT(2)R agonist, CGP42112. METHODS AND RESULTS: Apolipoprotein E-deficient (ApoE(-/-)) mice were fed a high fat (21 ) diet for 16 weeks, with subcutaneous infusions of CGP42112 (1, 5 or 10 mug/kg/min) administered via osmotic mini-pumps in the final 4 weeks. CGP42112 treatment at all doses significantly improved endothelial function (p
Original languageEnglish
Pages (from-to)281 - 287
Number of pages7
JournalInternational Journal of Cardiology
Volume169
Issue number4
DOIs
Publication statusPublished - 2013

Cite this

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title = "Direct AT{2} receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice",
abstract = "BACKGROUND: The angiotensin II type 2 receptor (AT(2)R) has been suggested to have an athero-protective role, however no studies have investigated the effect of direct stimulation of this receptor in atherosclerosis. Thus this study aimed to determine the effect of direct AT(2)R stimulation in setting of atherosclerosis, using the known AT(2)R agonist, CGP42112. METHODS AND RESULTS: Apolipoprotein E-deficient (ApoE(-/-)) mice were fed a high fat (21 ) diet for 16 weeks, with subcutaneous infusions of CGP42112 (1, 5 or 10 mug/kg/min) administered via osmotic mini-pumps in the final 4 weeks. CGP42112 treatment at all doses significantly improved endothelial function (p",
author = "{Tesanovic Kljajic}, Sonja and Widdop, {Robert Edward} and Antony Vinh and Welungoda, {Iresha Kumudu} and Sanja Bosnyak and Jones, {Emma Susan} and Gaspari, {Tracey Ann}",
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language = "English",
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journal = "International Journal of Cardiology",
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publisher = "Elsevier",
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Direct AT{2} receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice. / Tesanovic Kljajic, Sonja; Widdop, Robert Edward; Vinh, Antony; Welungoda, Iresha Kumudu; Bosnyak, Sanja; Jones, Emma Susan; Gaspari, Tracey Ann.

In: International Journal of Cardiology, Vol. 169, No. 4, 2013, p. 281 - 287.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Direct AT{2} receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice

AU - Tesanovic Kljajic, Sonja

AU - Widdop, Robert Edward

AU - Vinh, Antony

AU - Welungoda, Iresha Kumudu

AU - Bosnyak, Sanja

AU - Jones, Emma Susan

AU - Gaspari, Tracey Ann

PY - 2013

Y1 - 2013

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AB - BACKGROUND: The angiotensin II type 2 receptor (AT(2)R) has been suggested to have an athero-protective role, however no studies have investigated the effect of direct stimulation of this receptor in atherosclerosis. Thus this study aimed to determine the effect of direct AT(2)R stimulation in setting of atherosclerosis, using the known AT(2)R agonist, CGP42112. METHODS AND RESULTS: Apolipoprotein E-deficient (ApoE(-/-)) mice were fed a high fat (21 ) diet for 16 weeks, with subcutaneous infusions of CGP42112 (1, 5 or 10 mug/kg/min) administered via osmotic mini-pumps in the final 4 weeks. CGP42112 treatment at all doses significantly improved endothelial function (p

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U2 - 10.1016/j.ijcard.2013.09.015

DO - 10.1016/j.ijcard.2013.09.015

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VL - 169

SP - 281

EP - 287

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

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