Direct antiatherosclerotic effects of PPAR agonists

K. A M Jandeleit-Dahm; Anna Calkin; Chris Tikellis; Merlin Thomas

doi:10.1097/MOL.0b013e32831f1b18

Direct antiatherosclerotic effects of PPAR agonists

K. A M Jandeleit-Dahm, Anna Calkin, Chris Tikellis, Merlin Thomas

Research output: Contribution to journal › Review Article › Other › peer-review

28 Citations (Scopus)

Abstract

It is anticipated that the antiatherosclerotic effects of PPAR agonists observed in experimental studies will translate into reduced cardiovascular events. This promise is yet to be realized in short-to-medium term studies. Given the central role of the PPAR in gene regulation, particularly in metabolic states, it is possible that more targeted modulation of PPAR signalling may hold many rewards for the prevention of atherosclerosis.

Original language	English
Pages (from-to)	24-29
Number of pages	6
Journal	Current Opinion in Lipidology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1097/MOL.0b013e32831f1b18
Publication status	Published - Feb 2009
Externally published	Yes

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10.1097/MOL.0b013e32831f1b18

Cite this

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abstract = "It is anticipated that the antiatherosclerotic effects of PPAR agonists observed in experimental studies will translate into reduced cardiovascular events. This promise is yet to be realized in short-to-medium term studies. Given the central role of the PPAR in gene regulation, particularly in metabolic states, it is possible that more targeted modulation of PPAR signalling may hold many rewards for the prevention of atherosclerosis.",

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AU - Calkin, Anna

AU - Tikellis, Chris

AU - Thomas, Merlin

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AB - It is anticipated that the antiatherosclerotic effects of PPAR agonists observed in experimental studies will translate into reduced cardiovascular events. This promise is yet to be realized in short-to-medium term studies. Given the central role of the PPAR in gene regulation, particularly in metabolic states, it is possible that more targeted modulation of PPAR signalling may hold many rewards for the prevention of atherosclerosis.

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Direct antiatherosclerotic effects of PPAR agonists

Abstract

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