Dipyridophenazine complexes of cobalt(III): DNA photocleavage and photobiology

Alison Funston, Carleen Cullinane, Kenneth Ghiggino, W McFadyen, Stan Stylli, Peter Tregloan

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13 Citations (Scopus)

Abstract

The UV-visible spectroscopy and photochemistry of [Co( en)(2)(DPPZ)](ClO(4))(3) (DPPZ= dipyrido[3,2-a: 2 , 3 -c]phenazine) in the presence of plasmid DNA and the nucleoside 2 -deoxygaunosine have been investigated. Evidence for the intercalation of the complex with DNA and photoinduced DNA strand breakage is found. The structurally related complexes [Co(en)(2)(DPPN)] Cl(3) and [Co( en)(2)(DPPA)] Cl(2), where DPPN= benzo[ i] dipyrido[3,2- a: 2 , 3 -c] phenazine and DPPA = dipyrido[3,2- a: 2 , 3 -c] phenazine-11-carboxylic acid, have also been synthesized and characterized. In vitro cytotoxicity studies and photocytotoxicity studies of the complexes using the C6 rat glioma cell line are reported and indicate significant increases in toxicity following irradation.
Original languageEnglish
Pages (from-to)206 - 212
Number of pages7
JournalAustralian Journal of Chemistry
Volume58
Issue number3
DOIs
Publication statusPublished - 2005
Externally publishedYes

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