TY - JOUR
T1 - Dimensions of subcortical infarcts associated with first- to third-order branches of the basal ganglia arteries
AU - Phan, Thanh G
AU - van der Voort, Sanne
AU - Beare, Richard
AU - Ma, Henry Hin Kui
AU - Clissold, Benjamin G
AU - Holt, Michael
AU - Ly, John Van
AU - Foster, Emma
AU - Thong, Eleanor
AU - Stuckey, Stephen Leonard
AU - Cassell, Martin D
AU - Srikanth, Velandai
PY - 2013
Y1 - 2013
N2 - It has been described that lacunar infarct is characterized by its smallish size (15-20 mm) in the axial plane. However, the size of the basal ganglia artery responsible for this type of infarct is uncertain. Detection of small arterial occlusion is not possible with current angiography, hindering correlation of arterial occlusion with subcortical infarct size. Recently, investigators have published microangiographic templates of arteries supplying the basal ganglia. These templates display first-order (proximal) to third-order (distal) branching of these arteries and can help with estimating the likely site of arterial disease in subcortical infarcts. We correlated the dimensions of subcortical infarcts with the order of arterial branching described in a microangiographic template. Such data may provide further clues about the type of arteries associated with subcortical infarcts and assist in refining the concept of lacunar infarction. Method: Patients with subcortical infarcts on MR imaging (MRI) admitted to our institution between 2009 and 2011 were included in the study. Infarcts were manually segmented and registered to a standard brain template. These segmented infarcts were scaled and overlapped with published microangiographic templates, and used by 6 raters who independently estimated the branching order of arterial disease that might result in these infarcts. We used regression analysis to relate these ratings to infarct dimensions. Results: Among 777 patients, there were 33 (58 male) patients with subcortical infarcts. The mean age was 63.1 +/- 15.1 years. Infarct dimensions for the groups were as follows: group 1 (first-order branch): height 37.6 +/- 7.4 mm, horizontal width 21.2 +/- 11.6 mm, anterior-posterior length 36.8 +/- 20.1 mm; group 2 (second-order branch): height 25.2 +/- 7.9 mm, horizontal width 16.6 +/- 22.8 mm, anterior-posterior length 16.1 +/- 8.0 mm; group 3 (third-order branch): height 11.6 +/- 5.7 mm, axial width 5.3 +/- 3
AB - It has been described that lacunar infarct is characterized by its smallish size (15-20 mm) in the axial plane. However, the size of the basal ganglia artery responsible for this type of infarct is uncertain. Detection of small arterial occlusion is not possible with current angiography, hindering correlation of arterial occlusion with subcortical infarct size. Recently, investigators have published microangiographic templates of arteries supplying the basal ganglia. These templates display first-order (proximal) to third-order (distal) branching of these arteries and can help with estimating the likely site of arterial disease in subcortical infarcts. We correlated the dimensions of subcortical infarcts with the order of arterial branching described in a microangiographic template. Such data may provide further clues about the type of arteries associated with subcortical infarcts and assist in refining the concept of lacunar infarction. Method: Patients with subcortical infarcts on MR imaging (MRI) admitted to our institution between 2009 and 2011 were included in the study. Infarcts were manually segmented and registered to a standard brain template. These segmented infarcts were scaled and overlapped with published microangiographic templates, and used by 6 raters who independently estimated the branching order of arterial disease that might result in these infarcts. We used regression analysis to relate these ratings to infarct dimensions. Results: Among 777 patients, there were 33 (58 male) patients with subcortical infarcts. The mean age was 63.1 +/- 15.1 years. Infarct dimensions for the groups were as follows: group 1 (first-order branch): height 37.6 +/- 7.4 mm, horizontal width 21.2 +/- 11.6 mm, anterior-posterior length 36.8 +/- 20.1 mm; group 2 (second-order branch): height 25.2 +/- 7.9 mm, horizontal width 16.6 +/- 22.8 mm, anterior-posterior length 16.1 +/- 8.0 mm; group 3 (third-order branch): height 11.6 +/- 5.7 mm, axial width 5.3 +/- 3
UR - http://www.karger.com/Article/Pdf/348310
U2 - 10.1159/000348310
DO - 10.1159/000348310
M3 - Article
VL - 35
SP - 262
EP - 267
JO - Cerebrovascular Diseases
JF - Cerebrovascular Diseases
SN - 1015-9770
IS - 3
ER -