Diffusion tensor imaging evaluation of Axonal/White matter remodeling in a mouse model of diabetic stroke treated with novel p38 MAPK inhibitor, VCP979

Yu Cai, Chunqiang Lu, Tingting Xu, Yuanyuan Ma, Shudan Min, Peter Scammells, Binghui Wang, Shenghong Ju

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

© Copyright 2018 American Scientific Publishers All rights reserved. Type 2 diabetes mellitus (T2DM) is associated with severe axonal/white matter (WM) injury and poor functional outcomes following ischemic stroke. T2DM induces activation of p38 mitogen-activated protein kinases (MAPKs), which may be linked to the axonal/WM damage. In the present study, adult male C57BL/6J mice with streptozotocin (STZ)-induced T2DM mice were subjected to photothrombotic ischemic stroke and treatment with p38 MAPK inhibitors. The novel p38 MAPK inhibitor, VCP979, significantly promoted axonal/WM remodeling, neural progenitor cell migration, and improved functional recovery in T2DM mice. In vivo diffusion tensor imaging (DTI) revealed that the fractional anisotropy (FA) value, fiber number ratio, and fiber length were increased in the VCP979-treated group. Thus, VCP979 improves axonal/WM remodeling and functional outcomes in a diabetic mouse stroke model. DTI may aid in visualizing axonal/WM remodeling and evaluating the therapeutic efficacy of VCP979.
Original languageEnglish
Pages (from-to)585-593
Number of pages9
JournalJournal of Biomedical Nanotechnology
Volume14
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • Axonal/white matter
  • Diabetic stroke
  • Diffusion tensor imaging (DTI)
  • P38 MAPK inhibitor
  • VCP979

Cite this

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title = "Diffusion tensor imaging evaluation of Axonal/White matter remodeling in a mouse model of diabetic stroke treated with novel p38 MAPK inhibitor, VCP979",
abstract = "{\circledC} Copyright 2018 American Scientific Publishers All rights reserved. Type 2 diabetes mellitus (T2DM) is associated with severe axonal/white matter (WM) injury and poor functional outcomes following ischemic stroke. T2DM induces activation of p38 mitogen-activated protein kinases (MAPKs), which may be linked to the axonal/WM damage. In the present study, adult male C57BL/6J mice with streptozotocin (STZ)-induced T2DM mice were subjected to photothrombotic ischemic stroke and treatment with p38 MAPK inhibitors. The novel p38 MAPK inhibitor, VCP979, significantly promoted axonal/WM remodeling, neural progenitor cell migration, and improved functional recovery in T2DM mice. In vivo diffusion tensor imaging (DTI) revealed that the fractional anisotropy (FA) value, fiber number ratio, and fiber length were increased in the VCP979-treated group. Thus, VCP979 improves axonal/WM remodeling and functional outcomes in a diabetic mouse stroke model. DTI may aid in visualizing axonal/WM remodeling and evaluating the therapeutic efficacy of VCP979.",
keywords = "Axonal/white matter, Diabetic stroke, Diffusion tensor imaging (DTI), P38 MAPK inhibitor, VCP979",
author = "Yu Cai and Chunqiang Lu and Tingting Xu and Yuanyuan Ma and Shudan Min and Peter Scammells and Binghui Wang and Shenghong Ju",
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Diffusion tensor imaging evaluation of Axonal/White matter remodeling in a mouse model of diabetic stroke treated with novel p38 MAPK inhibitor, VCP979. / Cai, Yu; Lu, Chunqiang; Xu, Tingting; Ma, Yuanyuan; Min, Shudan; Scammells, Peter; Wang, Binghui; Ju, Shenghong.

In: Journal of Biomedical Nanotechnology, Vol. 14, No. 3, 01.03.2018, p. 585-593.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Cai, Yu

AU - Lu, Chunqiang

AU - Xu, Tingting

AU - Ma, Yuanyuan

AU - Min, Shudan

AU - Scammells, Peter

AU - Wang, Binghui

AU - Ju, Shenghong

PY - 2018/3/1

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N2 - © Copyright 2018 American Scientific Publishers All rights reserved. Type 2 diabetes mellitus (T2DM) is associated with severe axonal/white matter (WM) injury and poor functional outcomes following ischemic stroke. T2DM induces activation of p38 mitogen-activated protein kinases (MAPKs), which may be linked to the axonal/WM damage. In the present study, adult male C57BL/6J mice with streptozotocin (STZ)-induced T2DM mice were subjected to photothrombotic ischemic stroke and treatment with p38 MAPK inhibitors. The novel p38 MAPK inhibitor, VCP979, significantly promoted axonal/WM remodeling, neural progenitor cell migration, and improved functional recovery in T2DM mice. In vivo diffusion tensor imaging (DTI) revealed that the fractional anisotropy (FA) value, fiber number ratio, and fiber length were increased in the VCP979-treated group. Thus, VCP979 improves axonal/WM remodeling and functional outcomes in a diabetic mouse stroke model. DTI may aid in visualizing axonal/WM remodeling and evaluating the therapeutic efficacy of VCP979.

AB - © Copyright 2018 American Scientific Publishers All rights reserved. Type 2 diabetes mellitus (T2DM) is associated with severe axonal/white matter (WM) injury and poor functional outcomes following ischemic stroke. T2DM induces activation of p38 mitogen-activated protein kinases (MAPKs), which may be linked to the axonal/WM damage. In the present study, adult male C57BL/6J mice with streptozotocin (STZ)-induced T2DM mice were subjected to photothrombotic ischemic stroke and treatment with p38 MAPK inhibitors. The novel p38 MAPK inhibitor, VCP979, significantly promoted axonal/WM remodeling, neural progenitor cell migration, and improved functional recovery in T2DM mice. In vivo diffusion tensor imaging (DTI) revealed that the fractional anisotropy (FA) value, fiber number ratio, and fiber length were increased in the VCP979-treated group. Thus, VCP979 improves axonal/WM remodeling and functional outcomes in a diabetic mouse stroke model. DTI may aid in visualizing axonal/WM remodeling and evaluating the therapeutic efficacy of VCP979.

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