Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis

Scott C Kolbe, Mark Marriott, Anneke van der Walt, Joanne Fielding, Alexander Klistorner, Peter J Mitchell, Helmut Butzkueven, Trevor J Kilpatrick, Gary Francis Egan

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

PURPOSE: To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON). METHODS: Twenty-three patients with clinically definite relapsing-remitting MS and chronic unilateral ON and 14 neurologically healthy volunteers were monocularly tested with Sloan 100 , 2.5 , and 1.25 contrast visual acuity charts. Primary visual pathway and whole-brain WM injury were assessed with optical coherence tomography (OCT) and diffusion tensor imaging (DTI). OCT and DTI correlates of high- and low-contrast visual impairment were identified using correlation analyses. RESULTS: The MS patients displayed significantly reduced retinal nerve fiber layer (RNFL) thickness and altered optic nerve and radiation DTI measures compared with the controls. In the patients, 2.5 and 1.25 contrast letter acuity in the unaffected eye correlated significantly and independently with optic nerve and optic radiation DTI measures. Visual acuity in affected eyes did not correlate with optic nerve or optic radiation DTI measures, but did correlate with DTI measures in prefrontal and temporal brain regions that were shown to connect structurally to visual cortices. CONCLUSIONS: In unaffected eyes, visual impairment was associated with WM injury in the visual pathway. In contrast, irrecoverable visual impairment after ON was associated with injury to frontal WM, which potentially impairs the capacity for remapping visual processing.
Original languageEnglish
Pages (from-to)825 - 832
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume53
Issue number2
DOIs
Publication statusPublished - 2012

Cite this

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title = "Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis",
abstract = "PURPOSE: To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON). METHODS: Twenty-three patients with clinically definite relapsing-remitting MS and chronic unilateral ON and 14 neurologically healthy volunteers were monocularly tested with Sloan 100 , 2.5 , and 1.25 contrast visual acuity charts. Primary visual pathway and whole-brain WM injury were assessed with optical coherence tomography (OCT) and diffusion tensor imaging (DTI). OCT and DTI correlates of high- and low-contrast visual impairment were identified using correlation analyses. RESULTS: The MS patients displayed significantly reduced retinal nerve fiber layer (RNFL) thickness and altered optic nerve and radiation DTI measures compared with the controls. In the patients, 2.5 and 1.25 contrast letter acuity in the unaffected eye correlated significantly and independently with optic nerve and optic radiation DTI measures. Visual acuity in affected eyes did not correlate with optic nerve or optic radiation DTI measures, but did correlate with DTI measures in prefrontal and temporal brain regions that were shown to connect structurally to visual cortices. CONCLUSIONS: In unaffected eyes, visual impairment was associated with WM injury in the visual pathway. In contrast, irrecoverable visual impairment after ON was associated with injury to frontal WM, which potentially impairs the capacity for remapping visual processing.",
author = "Kolbe, {Scott C} and Mark Marriott and {van der Walt}, Anneke and Joanne Fielding and Alexander Klistorner and Mitchell, {Peter J} and Helmut Butzkueven and Kilpatrick, {Trevor J} and Egan, {Gary Francis}",
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Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis. / Kolbe, Scott C; Marriott, Mark; van der Walt, Anneke; Fielding, Joanne; Klistorner, Alexander; Mitchell, Peter J; Butzkueven, Helmut; Kilpatrick, Trevor J; Egan, Gary Francis.

In: Investigative Ophthalmology and Visual Science, Vol. 53, No. 2, 2012, p. 825 - 832.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis

AU - Kolbe, Scott C

AU - Marriott, Mark

AU - van der Walt, Anneke

AU - Fielding, Joanne

AU - Klistorner, Alexander

AU - Mitchell, Peter J

AU - Butzkueven, Helmut

AU - Kilpatrick, Trevor J

AU - Egan, Gary Francis

PY - 2012

Y1 - 2012

N2 - PURPOSE: To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON). METHODS: Twenty-three patients with clinically definite relapsing-remitting MS and chronic unilateral ON and 14 neurologically healthy volunteers were monocularly tested with Sloan 100 , 2.5 , and 1.25 contrast visual acuity charts. Primary visual pathway and whole-brain WM injury were assessed with optical coherence tomography (OCT) and diffusion tensor imaging (DTI). OCT and DTI correlates of high- and low-contrast visual impairment were identified using correlation analyses. RESULTS: The MS patients displayed significantly reduced retinal nerve fiber layer (RNFL) thickness and altered optic nerve and radiation DTI measures compared with the controls. In the patients, 2.5 and 1.25 contrast letter acuity in the unaffected eye correlated significantly and independently with optic nerve and optic radiation DTI measures. Visual acuity in affected eyes did not correlate with optic nerve or optic radiation DTI measures, but did correlate with DTI measures in prefrontal and temporal brain regions that were shown to connect structurally to visual cortices. CONCLUSIONS: In unaffected eyes, visual impairment was associated with WM injury in the visual pathway. In contrast, irrecoverable visual impairment after ON was associated with injury to frontal WM, which potentially impairs the capacity for remapping visual processing.

AB - PURPOSE: To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON). METHODS: Twenty-three patients with clinically definite relapsing-remitting MS and chronic unilateral ON and 14 neurologically healthy volunteers were monocularly tested with Sloan 100 , 2.5 , and 1.25 contrast visual acuity charts. Primary visual pathway and whole-brain WM injury were assessed with optical coherence tomography (OCT) and diffusion tensor imaging (DTI). OCT and DTI correlates of high- and low-contrast visual impairment were identified using correlation analyses. RESULTS: The MS patients displayed significantly reduced retinal nerve fiber layer (RNFL) thickness and altered optic nerve and radiation DTI measures compared with the controls. In the patients, 2.5 and 1.25 contrast letter acuity in the unaffected eye correlated significantly and independently with optic nerve and optic radiation DTI measures. Visual acuity in affected eyes did not correlate with optic nerve or optic radiation DTI measures, but did correlate with DTI measures in prefrontal and temporal brain regions that were shown to connect structurally to visual cortices. CONCLUSIONS: In unaffected eyes, visual impairment was associated with WM injury in the visual pathway. In contrast, irrecoverable visual impairment after ON was associated with injury to frontal WM, which potentially impairs the capacity for remapping visual processing.

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