Diffusion of carbon nanotubes with single-molecule fluorescence microscopy

Q. Lu, K. O. Freedman, R. Rao, G. Huang, J. Lee, L. L. Larcom, A. M. Rao, P. C. Ke

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20 Citations (Scopus)

Abstract

Single walled carbon nanotubes (SWNTs) are a promising gene and drug delivery system since their physical dimensions mimic nucleic acids. Towards this aim, the hydrophobicity of SWNTs was averted by coating with ribonucleic acid (RNA) polymer [poly(rU)] or bovine serum albumin (BSA) and the consequent diffusion of these synthetic-biomolecular hybrids was studied by single-molecule fluorescence microscopy. The diffusion coefficient for SWNT-poly(rU) was measured at 0.374±0.045 μm 2/s and for SWNT-BSA it was 0.442±0.046 μm 2/s. Our diffusion study provides a fundamental guidance to gene delivery using SWNT as transporters.

Original languageEnglish
Pages (from-to)6772-6775
Number of pages4
JournalJournal of Applied Physics
Volume96
Issue number11
DOIs
Publication statusPublished - 1 Dec 2004
Externally publishedYes

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