Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment

Stephen Rose, Katie McMahon, Andrew Janke, B O'Dowd, Grieg De zubicaray, Mark Strudwick, Jonathan Chalk

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170 Citations (Scopus)


BACKGROUND: Magnetic resonance diffusion tensor imaging (DTI) shows promise in the early detection of microstructural pathophysiological changes in the brain. OBJECTIVES: To measure microstructural differences in the brains of participants with amnestic mild cognitive impairment (MCI) compared with an age-matched control group using an optimised DTI technique with fully automated image analysis tools and to investigate the correlation between diffusivity measurements and neuropsychological performance scores across groups. METHODS: 34 participants (17 participants with MCI, 17 healthy elderly adults) underwent magnetic resonance imaging (MRI)-based DTI. To control for the effects of anatomical variation, diffusion images of all participants were registered to standard anatomical space. Significant statistical differences in diffusivity measurements between the two groups were determined on a pixel-by-pixel basis using gaussian random field theory. RESULTS: Significantly raised mean diffusivity measurements (p
Original languageEnglish
Pages (from-to)1122 - 1128
Number of pages7
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number10
Publication statusPublished - 2006
Externally publishedYes

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