Diffusion and Perfusion MR Imaging in Acute Stroke: Clinical Utility and Potential Limitations for Treatment Selection

Mathew Bateman, Lee Anne Slater, Thabele M Leslie-Mazwi, Claus Ziegler Simonsen, Stephen Stuckey, Ronil V. Chandra

Research output: Contribution to journalReview ArticleOtherpeer-review

10 Citations (Scopus)

Abstract

Magnetic resonance (MR) diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) offer unique insight into acute ischemic stroke pathophysiology. These techniques may offer the ability to apply pathophysiology to accurately individualize acute stroke reperfusion treatment, including extending the opportunity of reperfusion treatment to well beyond the current time-based treatment windows. This review examines the use of DWI and PWI in the major stroke trials, their current clinical utility, and potential limitations for reperfusion treatment selection. DWI and PWI continue to be investigated in ongoing randomized controlled trials, and continued research into these techniques will help achieve the goal of tissue-based decision making and individualized acute stroke treatment.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalTopics in Magnetic Resonance Imaging
Volume26
Issue number2
DOIs
Publication statusPublished - 1 Apr 2017

Keywords

  • diffusion imaging
  • MRI
  • perfusion imaging
  • reperfusion
  • stroke
  • thrombolysis

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