TY - JOUR
T1 - Diffuse idiopathic skeletal hyperostosis and new bone formation in male gouty subjects - A radiologic study
AU - Littlejohn, G. O.
AU - Hall, S.
PY - 1982/6/1
Y1 - 1982/6/1
N2 - Ninety-nine males with gout were identified and their radiographs examined for features of vertebral hyperostosis and entheseal changes (diffuse idiopathic skeletal hyperostosis, DISH). Of patients over the age of 45 years 43% fulfilled criteria for diagnosis of DISH. New bone formation in other regions of the skeleton was also common. The overhanging margin sign, seen in well developed tophi, was noted only in patients with prominent new bone formation elsewhere in their skeleton. Some of the radiologic manifestations of gout may be modified by a co-existent tendency, in these patients, to form new bone. It is suggested that a common metabolic factor, possibly hyperinsulinaemia, underlies the association of gout and hyperostosis.
AB - Ninety-nine males with gout were identified and their radiographs examined for features of vertebral hyperostosis and entheseal changes (diffuse idiopathic skeletal hyperostosis, DISH). Of patients over the age of 45 years 43% fulfilled criteria for diagnosis of DISH. New bone formation in other regions of the skeleton was also common. The overhanging margin sign, seen in well developed tophi, was noted only in patients with prominent new bone formation elsewhere in their skeleton. Some of the radiologic manifestations of gout may be modified by a co-existent tendency, in these patients, to form new bone. It is suggested that a common metabolic factor, possibly hyperinsulinaemia, underlies the association of gout and hyperostosis.
KW - Ankylosing hyperostosis
KW - Diffuse idiopathic skeletal hyperostosis
KW - Gout
KW - New bone
UR - http://www.scopus.com/inward/record.url?scp=0020323212&partnerID=8YFLogxK
U2 - 10.1007/BF00541250
DO - 10.1007/BF00541250
M3 - Article
C2 - 6817406
AN - SCOPUS:0020323212
VL - 2
SP - 83
EP - 86
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 2
ER -