Oxidative stress is implicated in the pathogenesis and/or complications of hypertension and/or diabetes mellitus. A combination of these disorders increases the risk of developing cardiovascular events. This study investigated the effects of streptozotocin (60 mg/kg; ip)-induced diabetes on blood pressure, oxidative stress and effects of honey on these parameters in the kidneys of streptozotocin-induced diabetic Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR).
Erejuwa, O., Sulaiman, S., Ab Wahab, M. S., Sirajudeen, K., Md Salleh, M., & Gurtu, S. (2011). Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic Wistar-Kyoto rats and spontaneously hypertensive rats: Effects of antioxidant (honey) treatment. International Journal of Molecular Sciences, 12(3), 1888 - 1907. https://doi.org/10.3390/ijms12031888