Differential responses to blood pressure and oxidative stress in streptozotocin-induced diabetic Wistar-Kyoto rats and spontaneously hypertensive rats: Effects of antioxidant (honey) treatment

Omotayo Erejuwa, Siti Sulaiman, Mohd Suhaimi Ab Wahab, K Sirajudeen, Md Md Salleh, Sunil Gurtu

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    Abstract

    Oxidative stress is implicated in the pathogenesis and/or complications of hypertension and/or diabetes mellitus. A combination of these disorders increases the risk of developing cardiovascular events. This study investigated the effects of streptozotocin (60 mg/kg; ip)-induced diabetes on blood pressure, oxidative stress and effects of honey on these parameters in the kidneys of streptozotocin-induced diabetic Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR).
    Original languageEnglish
    Pages (from-to)1888 - 1907
    Number of pages20
    JournalInternational Journal of Molecular Sciences
    Volume12
    Issue number3
    DOIs
    Publication statusPublished - 2011

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