Differential response to resistance training in CHF according to ACE genotype

Andrew D Williams, Mitchell J. Anderson, Steve Selig, Michael F Carey, Mark A. Febbraio, Alan Hayes, Deidre Toia, Stephen B Harrap, David L Hare

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7 Citations (Scopus)


Background: The Angiotensin Converting Enzyme (ACE) gene may influence the risk of heart disease and the response to various forms of exercise training may be at least partly dependent on the ACE genotype. We aimed to determine the effect of ACE genotype on the response to moderate intensity circuit resistance training in chronic heart failure (CHF) patients. Methods: The relationship between ACE genotype and the response to 11 weeks of resistance exercise training was determined in 37 CHF patients (New York Heart Association Functional Class = 2.3 ± 0.5; left ventricular ejection fraction 28 ± 7%; age 64 ± 12 years; 32:5 male:female) who were randomised to either resistance exercise (n = 19) or inactive control group (n = 18). Outcome measures included V̇O2peak, peak power output and muscle strength and endurance. ACE genotype was determined using standard methods. Results: At baseline, patients who were homozygous for the I allele had higher V̇O2peak (p = 0.02) and peak power (p = 0.003) compared to patients who were homozygous for the D allele. Patients with the D allele, who were randomised to resistance training, compared to non-exercising controls, had greater peak power increases (ID p < 0.001; DD p < 0.001) when compared with patients homozygous for the I allele, who did not improve. No significant genotype-dependent changes were observed in V̇O2peak, muscle strength, muscle endurance or lactate threshold. Conclusion: ACE genotype may have a role in exercise tolerance in CHF and could also influence the effectiveness of resistance training in this condition.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalInternational Journal of Cardiology
Issue number3
Publication statusPublished - 16 Jun 2011
Externally publishedYes


  • Exercise
  • Genes
  • Heart failure

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