Projects per year
Abstract
Zhang et al. show that the non-peptide GLP-1R agonist PF 06882961, but not CHU-128, was able to closely mimic the in vitro pharmacological fingerprint of GLP-1. These pharmacological activities could be rationalized from high-resolution structures that provide a novel template for the design of new agonists targeting the GLP-1R.
Original language | English |
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Pages (from-to) | 485-500 |
Number of pages | 16 |
Journal | Molecular Cell |
Volume | 80 |
Issue number | 3 |
DOIs | |
Publication status | Published - 5 Nov 2020 |
Keywords
- cryoelectron microscopy
- G-protein-coupled receptor
- GLP-1
- glucagon-like peptide-1 receptor
- non-peptide agonists
Projects
- 3 Finished
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Molecular control of efficacy at glucagon family of receptors
Wootten, D. & Wu, B.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/24
Project: Research
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Translating membrane proteins into therapeutics; from bedside to bench
Sexton, P., Christopoulos, A., Pantelis, C. & Parton, R. G.
1/01/19 → 31/12/23
Project: Research
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The structural basis for biased agonism at the glucagon-like peptide-1 receptor
Wootten, D. & Miller, L.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
Equipment
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MASSIVE
David Powell (Manager) & Gin Tan (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility
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Ramaciotti Centre for Cryo-Electron Microscopy
Georg Ramm (Manager), Simon Andrew Crawford (Operator), Hariprasad Venugopal (Operator), Joan Marea Clark (Operator) & Gediminas Gervinskas (Operator)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility