Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment

Rachel Soon; Roger Nation; Stewart Cockram; Jennifer Moffatt; Marina Harper; Ben Adler; John Boyce; Ian Larson; Jian Li

doi:10.1093/jac/dkq422

Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment

Rachel Soon, Roger Nation, Stewart Cockram, Jennifer Moffatt, Marina Harper, Ben Adler, John Boyce, Ian Larson, Jian Li

Research output: Contribution to journal › Article › Research › peer-review

104 Citations (Scopus)

Abstract

electrostatic forces mediate the initial interaction between cationic colistin and Gram-negative bacterial cells. Lipopolysaccharide (LPS) loss mediates colistin resistance in some A. baumannii strains. Our aim was to determine the surface charge of colistin-susceptible and -resistant A. baumannii as a function of growth phase and in response to polymyxin treatment.

Original language	English
Pages (from-to)	126 - 133
Number of pages	8
Journal	Journal of Antimicrobial Chemotherapy
Volume	66
Issue number	1
DOIs	https://doi.org/10.1093/jac/dkq422
Publication status	Published - 2011

Access to Document

10.1093/jac/dkq422

Optimizing dosing of colistin for infections resistant to all other antibiotics.
Nation, R. (Primary Chief Investigator (PCI)) & Li, J. (Chief Investigator (CI))
NIH - National Institutes of Health (United States of America)
15/09/08 → 31/08/12
Project: Research
Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.
Nation, R. (Primary Chief Investigator (PCI)), Li, J. (Chief Investigator (CI)), Forrest, A. (Partner Investigator (PI)), Paterson, D. L. (Partner Investigator (PI)) & Tsuji, B. T. (Partner Investigator (PI))
NIH - National Institutes of Health (United States of America)
15/07/08 → 30/06/12
Project: Research

Cite this

Soon, R., Nation, R., Cockram, S., Moffatt, J., Harper, M., Adler, B., Boyce, J., Larson, I., & Li, J. (2011). Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment. Journal of Antimicrobial Chemotherapy, 66(1), 126 - 133. https://doi.org/10.1093/jac/dkq422

@article{805d21fe081143439f1d9ee37f2e7c21,

title = "Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment",

abstract = "electrostatic forces mediate the initial interaction between cationic colistin and Gram-negative bacterial cells. Lipopolysaccharide (LPS) loss mediates colistin resistance in some A. baumannii strains. Our aim was to determine the surface charge of colistin-susceptible and -resistant A. baumannii as a function of growth phase and in response to polymyxin treatment.",

author = "Rachel Soon and Roger Nation and Stewart Cockram and Jennifer Moffatt and Marina Harper and Ben Adler and John Boyce and Ian Larson and Jian Li",

year = "2011",

doi = "10.1093/jac/dkq422",

language = "English",

volume = "66",

pages = "126 -- 133",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "1",

}

Soon, R, Nation, R, Cockram, S, Moffatt, J, Harper, M , Adler, B , Boyce, J , Larson, I & Li, J 2011, 'Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment', Journal of Antimicrobial Chemotherapy, vol. 66, no. 1, pp. 126 - 133. https://doi.org/10.1093/jac/dkq422

Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment. / Soon, Rachel; Nation, Roger; Cockram, Stewart et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 66, No. 1, 2011, p. 126 - 133.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment

AU - Soon, Rachel

AU - Nation, Roger

AU - Cockram, Stewart

AU - Moffatt, Jennifer

AU - Harper, Marina

AU - Adler, Ben

AU - Boyce, John

AU - Larson, Ian

AU - Li, Jian

PY - 2011

Y1 - 2011

N2 - electrostatic forces mediate the initial interaction between cationic colistin and Gram-negative bacterial cells. Lipopolysaccharide (LPS) loss mediates colistin resistance in some A. baumannii strains. Our aim was to determine the surface charge of colistin-susceptible and -resistant A. baumannii as a function of growth phase and in response to polymyxin treatment.

AB - electrostatic forces mediate the initial interaction between cationic colistin and Gram-negative bacterial cells. Lipopolysaccharide (LPS) loss mediates colistin resistance in some A. baumannii strains. Our aim was to determine the surface charge of colistin-susceptible and -resistant A. baumannii as a function of growth phase and in response to polymyxin treatment.

U2 - 10.1093/jac/dkq422

DO - 10.1093/jac/dkq422

M3 - Article

C2 - 21081544

SN - 0305-7453

VL - 66

SP - 126

EP - 133

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 1

ER -

Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment

Abstract

Access to Document

Projects

Optimizing dosing of colistin for infections resistant to all other antibiotics.

Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.

Cite this