Different surface charge of colistin-susceptible and -resistant acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment

Rachel Soon, Roger Nation, Stewart Cockram, Jennifer Moffatt, Marina Harper, Ben Adler, John Boyce, Ian Larson, Jian Li

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Abstract

electrostatic forces mediate the initial interaction between cationic colistin and Gram-negative bacterial cells. Lipopolysaccharide (LPS) loss mediates colistin resistance in some A. baumannii strains. Our aim was to determine the surface charge of colistin-susceptible and -resistant A. baumannii as a function of growth phase and in response to polymyxin treatment.
Original languageEnglish
Pages (from-to)126 - 133
Number of pages8
JournalJournal of Antimicrobial Chemotherapy
Volume66
Issue number1
DOIs
Publication statusPublished - 2011

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