Different stimulation frequencies alter synchronous fluctuations in motor evoked potential amplitude of intrinsic hand muscles - a TMS study

Martin V. Sale, Nigel C. Rogasch, Michael A. Nordstrom

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The amplitude of motor-evoked potentials (MEPs) elicited with transcranial magnetic stimulation (TMS) varies from trial-to-trial. Synchronous oscillations in cortical neuronal excitability contribute to this variability, however it is not known how different frequencies of stimulation influence MEP variability, and whether these oscillations are rhythmic or aperiodic. We stimulated the motor cortex with TMS at different regular (i.e. rhythmic) rates, and compared this with pseudo-random (aperiodic) timing. In 18 subjects, TMS was applied at three regular frequencies (0.05 Hz, 0.2 Hz, 1 Hz) and one aperiodic frequency (mean 0.2 Hz). MEPs (n = 50) were recorded from three intrinsic hand muscles of the left hand with different functional and anatomical relations. MEP amplitude correlation was highest for the functionally related muscle pair, less for the anatomically related muscle pair and least for the functionally-and anatomically-unrelated muscle pair. MEP correlations were greatest with 1 Hz, and least for stimulation at 0.05 Hz. Corticospinal neuron synchrony is higher with shorter TMS intervals. Further, corticospinal neuron synchrony is similar irrespective of whether the stimulation is periodic or aperiodic. These findings suggest TMS frequency is a crucial consideration for studies using TMS to probe correlated activity between muscle pairs
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalFrontiers in Human Neuroscience
Volume10
DOIs
Publication statusPublished - Mar 2016

Keywords

  • ttranscranial magnetic stimulation
  • cortical oscillations
  • motor-evoked potential
  • motor cortex
  • first dorsal interosseous
  • abductor pollicis brevis
  • abductor digiti minimi

Cite this

@article{b0327e3a54bf4aa5ba6ea5423e6eedf9,
title = "Different stimulation frequencies alter synchronous fluctuations in motor evoked potential amplitude of intrinsic hand muscles - a TMS study",
abstract = "The amplitude of motor-evoked potentials (MEPs) elicited with transcranial magnetic stimulation (TMS) varies from trial-to-trial. Synchronous oscillations in cortical neuronal excitability contribute to this variability, however it is not known how different frequencies of stimulation influence MEP variability, and whether these oscillations are rhythmic or aperiodic. We stimulated the motor cortex with TMS at different regular (i.e. rhythmic) rates, and compared this with pseudo-random (aperiodic) timing. In 18 subjects, TMS was applied at three regular frequencies (0.05 Hz, 0.2 Hz, 1 Hz) and one aperiodic frequency (mean 0.2 Hz). MEPs (n = 50) were recorded from three intrinsic hand muscles of the left hand with different functional and anatomical relations. MEP amplitude correlation was highest for the functionally related muscle pair, less for the anatomically related muscle pair and least for the functionally-and anatomically-unrelated muscle pair. MEP correlations were greatest with 1 Hz, and least for stimulation at 0.05 Hz. Corticospinal neuron synchrony is higher with shorter TMS intervals. Further, corticospinal neuron synchrony is similar irrespective of whether the stimulation is periodic or aperiodic. These findings suggest TMS frequency is a crucial consideration for studies using TMS to probe correlated activity between muscle pairs",
keywords = "ttranscranial magnetic stimulation, cortical oscillations, motor-evoked potential, motor cortex, first dorsal interosseous, abductor pollicis brevis, abductor digiti minimi",
author = "Sale, {Martin V.} and Rogasch, {Nigel C.} and Nordstrom, {Michael A.}",
year = "2016",
month = "3",
doi = "10.3389/fnhum.2016.00100",
language = "English",
volume = "10",
pages = "1--9",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Research Foundation",

}

Different stimulation frequencies alter synchronous fluctuations in motor evoked potential amplitude of intrinsic hand muscles - a TMS study. / Sale, Martin V.; Rogasch, Nigel C.; Nordstrom, Michael A.

In: Frontiers in Human Neuroscience, Vol. 10, 03.2016, p. 1-9.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Different stimulation frequencies alter synchronous fluctuations in motor evoked potential amplitude of intrinsic hand muscles - a TMS study

AU - Sale, Martin V.

AU - Rogasch, Nigel C.

AU - Nordstrom, Michael A.

PY - 2016/3

Y1 - 2016/3

N2 - The amplitude of motor-evoked potentials (MEPs) elicited with transcranial magnetic stimulation (TMS) varies from trial-to-trial. Synchronous oscillations in cortical neuronal excitability contribute to this variability, however it is not known how different frequencies of stimulation influence MEP variability, and whether these oscillations are rhythmic or aperiodic. We stimulated the motor cortex with TMS at different regular (i.e. rhythmic) rates, and compared this with pseudo-random (aperiodic) timing. In 18 subjects, TMS was applied at three regular frequencies (0.05 Hz, 0.2 Hz, 1 Hz) and one aperiodic frequency (mean 0.2 Hz). MEPs (n = 50) were recorded from three intrinsic hand muscles of the left hand with different functional and anatomical relations. MEP amplitude correlation was highest for the functionally related muscle pair, less for the anatomically related muscle pair and least for the functionally-and anatomically-unrelated muscle pair. MEP correlations were greatest with 1 Hz, and least for stimulation at 0.05 Hz. Corticospinal neuron synchrony is higher with shorter TMS intervals. Further, corticospinal neuron synchrony is similar irrespective of whether the stimulation is periodic or aperiodic. These findings suggest TMS frequency is a crucial consideration for studies using TMS to probe correlated activity between muscle pairs

AB - The amplitude of motor-evoked potentials (MEPs) elicited with transcranial magnetic stimulation (TMS) varies from trial-to-trial. Synchronous oscillations in cortical neuronal excitability contribute to this variability, however it is not known how different frequencies of stimulation influence MEP variability, and whether these oscillations are rhythmic or aperiodic. We stimulated the motor cortex with TMS at different regular (i.e. rhythmic) rates, and compared this with pseudo-random (aperiodic) timing. In 18 subjects, TMS was applied at three regular frequencies (0.05 Hz, 0.2 Hz, 1 Hz) and one aperiodic frequency (mean 0.2 Hz). MEPs (n = 50) were recorded from three intrinsic hand muscles of the left hand with different functional and anatomical relations. MEP amplitude correlation was highest for the functionally related muscle pair, less for the anatomically related muscle pair and least for the functionally-and anatomically-unrelated muscle pair. MEP correlations were greatest with 1 Hz, and least for stimulation at 0.05 Hz. Corticospinal neuron synchrony is higher with shorter TMS intervals. Further, corticospinal neuron synchrony is similar irrespective of whether the stimulation is periodic or aperiodic. These findings suggest TMS frequency is a crucial consideration for studies using TMS to probe correlated activity between muscle pairs

KW - ttranscranial magnetic stimulation

KW - cortical oscillations

KW - motor-evoked potential

KW - motor cortex

KW - first dorsal interosseous

KW - abductor pollicis brevis

KW - abductor digiti minimi

UR - http://journal.frontiersin.org/article/10.3389/fnhum.2016.00100/full

U2 - 10.3389/fnhum.2016.00100

DO - 10.3389/fnhum.2016.00100

M3 - Article

VL - 10

SP - 1

EP - 9

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

ER -