Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow

C. J H Porter, S. M. Moghimi, M. C. Davies, S. S. Davis, L. Illum

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Abstract

Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume83
Issue number1-3
DOIs
Publication statusPublished - 30 Jun 1982
Externally publishedYes

Keywords

  • Bone marrow
  • Microsphere
  • Poloxamer 407
  • Rabbit
  • Rat

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