Abstract
Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.
| Original language | English |
|---|---|
| Pages (from-to) | 273-276 |
| Number of pages | 4 |
| Journal | International Journal of Pharmaceutics |
| Volume | 83 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 30 Jun 1982 |
| Externally published | Yes |
Keywords
- Bone marrow
- Microsphere
- Poloxamer 407
- Rabbit
- Rat
Cite this
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Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow. / Porter, C. J H; Moghimi, S. M.; Davies, M. C.; Davis, S. S.; Illum, L.
In: International Journal of Pharmaceutics, Vol. 83, No. 1-3, 30.06.1982, p. 273-276.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow
AU - Porter, C. J H
AU - Moghimi, S. M.
AU - Davies, M. C.
AU - Davis, S. S.
AU - Illum, L.
PY - 1982/6/30
Y1 - 1982/6/30
N2 - Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.
AB - Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.
KW - Bone marrow
KW - Microsphere
KW - Poloxamer 407
KW - Rabbit
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0026690944&partnerID=8YFLogxK
U2 - 10.1016/0378-5173(82)90033-3
DO - 10.1016/0378-5173(82)90033-3
M3 - Article
VL - 83
SP - 273
EP - 276
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-3
ER -