Differences in the acute and chronic antihypertensive effects of lisinopril and enalapril assessed by ambulatory blood pressure monitoring

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Abstract

Although lisinopril and enalapril are equipotent angiotensin converting enzyme (ACE) inhibitors lisinopril has been reported to produce greater inhibition of plasma ACE 24 hours after single doses. This study compared the antihypertensive effects of once daily 10mg doses of the drugs using a randomised, double-blind, two period cross-over design with ambulatory blood pressure monitoring. Lisinopril lowered mean 24 hour systolic blood pressure significantly more than enalapril after 4 weeks of treatment (14/7.2/1mmHg & 9/6.2/1mmHg, respectively, adjusted SBP difference 4.8mmHg, P<0.01). This difference was confined to the second 12 hours of the daily dosage interval (adjusted SBP difference 13-24 hours after dosing 9.9mmHg, P<0.001). The diastolic pressure showed a similar trend but this was not statistically significant. The side effects of each.

Original languageEnglish
Pages (from-to)71-89
Number of pages19
JournalClinical and Experimental Hypertension
Volume15
Issue number1
DOIs
Publication statusPublished - 1 Jan 1993

Keywords

  • ACE inhibitors
  • Ambulatory blood pressure monitoring
  • Enalapril
  • Hypertension
  • Lisinopril

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