Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

Stephanie Tortorella, Simon G Royce, Paul V Licciardi, Tom C Karagiannis

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Abstract

SIGNIFICANCE: Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has been extensively studied due to its apparent health-promoting properties in disease and limited toxicity in normal tissue. Recent Studies: Recent identification of a sub-population of tumor cells with stem cell-like self-renewal capacity that may be responsible for relapse, metastasis, and resistance, as a potential target of the dietary compound, may be an important aspect of sulforaphane chemoprevention. Evidence also suggests that sulforaphane may target the epigenetic alterations observed in specific cancers, reversing aberrant changes in gene transcription through mechanisms of histone deacetylase inhibition, global demethylation, and microRNA modulation. CRITICAL ISSUES: In this review, we discuss the biochemical and biological properties of sulforaphane with a particular emphasis on the anticancer properties of the dietary compound. Sulforaphane possesses the capacity to intervene in multistage carcinogenesis through the modulation and/or regulation of important cellular mechanisms. The inhibition of phase I enzymes that are responsible for the activation of pro-carcinogens, and the induction of phase II enzymes that are critical in mutagen elimination are well-characterized chemopreventive properties. Furthermore, sulforaphane mediates a number of anticancer pathways, including the activation of apoptosis, induction of cell cycle arrest, and inhibition of NFkappaB. FUTURE DIRECTIONS: Further characterization of the chemopreventive properties of sulforaphane and its capacity to be selectively toxic to malignant cells are warranted to potentially establish the clinical utility of the dietary compound as an anti-cancer compound alone, and in combination with clinically relevant therapeutic and management strategies.
Original languageEnglish
Pages (from-to)1382 - 1424
Number of pages43
JournalAntioxidants and Redox Signaling
Volume22
Issue number16
DOIs
Publication statusPublished - 2015

Cite this

Tortorella, Stephanie ; Royce, Simon G ; Licciardi, Paul V ; Karagiannis, Tom C. / Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition. In: Antioxidants and Redox Signaling. 2015 ; Vol. 22, No. 16. pp. 1382 - 1424.
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Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition. / Tortorella, Stephanie; Royce, Simon G; Licciardi, Paul V; Karagiannis, Tom C.

In: Antioxidants and Redox Signaling, Vol. 22, No. 16, 2015, p. 1382 - 1424.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

AU - Tortorella, Stephanie

AU - Royce, Simon G

AU - Licciardi, Paul V

AU - Karagiannis, Tom C

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JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

SN - 1523-0864

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